{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mohr SM"],"funding":["NIDDK NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","NINDS NIH HHS"],"pagination":["5803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11236985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) lasts for 5-7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24-48-h periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger during IBAs. These squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons exhibit reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center."],"journal":["Nature communications"],"pubmed_title":["Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation."],"pmcid":["PMC11236985"],"funding_grant_id":["R01 NS126271","R01N097547","1R01NS126271","R01 NS097547","R01 DK126447"],"pubmed_authors":["Platt MP","Varela L","Cao H","Merriman DK","Gracheva EO","Kristant A","Bagriantsev SN","Dai Pra R","Mohr SM","Feketa VV","Shanabrough M","Horvath TL"],"additional_accession":[]},"is_claimable":false,"name":"Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation.","description":"Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) lasts for 5-7 months and comprises weeks of hypometabolic, hypothermic torpor interspersed with 24-48-h periods of an active-like interbout arousal (IBA) state. We show that ground squirrels, who endure the entire hibernation season without food, have negligible hunger during IBAs. These squirrels exhibit reversible inhibition of the hypothalamic feeding center, such that hypothalamic arcuate nucleus neurons exhibit reduced sensitivity to the orexigenic and anorexigenic effects of ghrelin and leptin, respectively. However, hypothalamic infusion of thyroid hormone during an IBA is sufficient to rescue hibernation anorexia. Our results reveal that thyroid hormone deficiency underlies hibernation anorexia and demonstrate the functional flexibility of the hypothalamic feeding center.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2024-12-04T10:16:35.201Z","creation":"2024-12-04T10:16:35.201Z"},"accession":"S-EPMC11236985","cross_references":{"pubmed":["38987241"],"doi":["10.1038/s41467-024-49996-2"]}}