{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li H"],"funding":["National Key Research & Development Program of Liyin","National Key Research & Development Program of Liyin"],"pagination":["15920"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11237145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["With the gradual liberalization of the three-child policy and the development of assisted reproductive technology in China, the number of women with high-risk pregnancies is gradually increasing. In this study, 4211 fetuses who underwent chromosomal microarray analysis (CMA) with high-risk prenatal indications were analysed. The results showed that the overall prenatal detection rate of CMA was 11.4% (480/4211), with detection rates of 5.82% (245/4211) for abnormal chromosome numbers and 5.58% (235/4211) for copy number variants. Additionally, the detection rates of clinically significant copy number variants were 3.78% (159/4211) and 1.8% (76/4211) for variants of uncertain significance. The detection rates of fetal chromosomal abnormalities were 6.42% (30/467) for pregnant women with adv"],"journal":["Scientific reports"],"pubmed_title":["Chromosomal abnormalities detected by chromosomal microarray analysis and pregnancy outcomes of 4211 fetuses with high-risk prenatal indications."],"pmcid":["PMC11237145"],"funding_grant_id":["2022YX0111"],"pubmed_authors":["Li H","Qiu J","Zhu J","Hu J","Wu Q","Zhang L"],"additional_accession":[]},"is_claimable":false,"name":"Chromosomal abnormalities detected by chromosomal microarray analysis and pregnancy outcomes of 4211 fetuses with high-risk prenatal indications.","description":"With the gradual liberalization of the three-child policy and the development of assisted reproductive technology in China, the number of women with high-risk pregnancies is gradually increasing. In this study, 4211 fetuses who underwent chromosomal microarray analysis (CMA) with high-risk prenatal indications were analysed. The results showed that the overall prenatal detection rate of CMA was 11.4% (480/4211), with detection rates of 5.82% (245/4211) for abnormal chromosome numbers and 5.58% (235/4211) for copy number variants. Additionally, the detection rates of clinically significant copy number variants were 3.78% (159/4211) and 1.8% (76/4211) for variants of uncertain significance. The detection rates of fetal chromosomal abnormalities were 6.42% (30/467) for pregnant women with adv","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-05T15:46:55.987Z","creation":"2025-04-05T15:46:55.987Z"},"accession":"S-EPMC11237145","cross_references":{"pubmed":["38987582"],"doi":["10.1038/s41598-024-67123-5"]}}