biostudies-literatureSun R-YResearch Grants Council of the Hong Kong Special Administrative Region, ChinaInnovation Team Project of Guangdong UniversityNational Natural Science Foundation of ChinaLocal Innovative and Research Teams Project of Guangdong Pearl River Talents Programe0116423https://www.ebi.ac.uk/biostudies/studies/S-EPMC11237462biostudies-literatureUnknown9(6)<i>Salmonella</i> 4,[5],12:i:-, a monophasic variant of <i>Salmonella</i> Typhimurium, has emerged as a global cause of multidrug-resistant salmonellosis and has become endemic in many developing and developed countries, especially in China. Here, we have sequenced 352 clinical isolates in Guangdong, China, during 2009-2019 and performed a large-scale collection of <i>Salmonella</i> 4,[5],12:i:- with whole genome sequencing (WGS) data across the globe, to better understand the population structure, antimicrobial resistance (AMR) genomic characterization, and transmission routes of <i>Salmonella</i> 4,[5],12:i:- across Guangdong. <i>Salmonella</i> 4,[5],12:i:- strains showed broad genetic diversity; Guangdong isolates were found to be widely distributed among the global lineages. Of note, wmSystemsAntimicrobial resistance and population genomics of emerging multidrug-resistant <i>Salmonella</i> 4,[5],12:i:- in Guangdong, China.PMC11237462322730662019KCXTD001C6026-19GC7003-20G321210042019BT02N054Sun R-YChen K-CFang L-XDai J-JWai Chi Chan ELiu Y-HChen SKe B-XKe C-WSun JLiao X-PfalseAntimicrobial resistance and population genomics of emerging multidrug-resistant <i>Salmonella</i> 4,[5],12:i:- in Guangdong, China.<i>Salmonella</i> 4,[5],12:i:-, a monophasic variant of <i>Salmonella</i> Typhimurium, has emerged as a global cause of multidrug-resistant salmonellosis and has become endemic in many developing and developed countries, especially in China. Here, we have sequenced 352 clinical isolates in Guangdong, China, during 2009-2019 and performed a large-scale collection of <i>Salmonella</i> 4,[5],12:i:- with whole genome sequencing (WGS) data across the globe, to better understand the population structure, antimicrobial resistance (AMR) genomic characterization, and transmission routes of <i>Salmonella</i> 4,[5],12:i:- across Guangdong. <i>Salmonella</i> 4,[5],12:i:- strains showed broad genetic diversity; Guangdong isolates were found to be widely distributed among the global lineages. Of note, w2024-01-01T00:00:00Z2024 Jun2026-06-01T07:34:59.401Z2025-04-07T12:05:20.872ZS-EPMC112374623874758210.1128/msystems.01164-23