{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ibanez-Prada ED"],"funding":["Universidad de La Sabana","Universidad de La Sabana (University of La Sabana)","MSD Colombia"],"pagination":["e0171423"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11237484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["In this study, the genetic differences and clinical impact of the carbapenemase-encoding genes among the community and healthcare-acquired infections were assessed. This retrospective, multicenter cohort study was conducted in Colombia and included patients infected with carbapenem-resistant Gram-negative rods between 2017 and 2021. Carbapenem resistance was identified by Vitek, and carbapenemase-encoding genes were identified by whole-genome sequencing (WGS) to classify the alleles and sequence types (STs). Descriptive statistics were used to determine the association of any pathogen or gene with clinical outcomes. A total of 248 patients were included, of which only 0.8% (2/248) had community-acquired infections. Regarding the identified bacteria, the most prevalent pathogens were <i>Pse"],"journal":["Microbiology spectrum"],"pubmed_title":["Molecular characterization and descriptive analysis of carbapenemase-producing Gram-negative rod infections in Bogota, Colombia."],"pmcid":["PMC11237484"],"funding_grant_id":["001","MED-315-2021"],"pubmed_authors":["Fuentes YV","Wyres KL","Serrano-Mayorga CC","Medina S","Stewardson AJ","Reyes LF","Gamboa-Silva E","Judd LM","Josa DF","Ibanez-Prada ED","Harshegyi T","Urrego-Reyes J","Mendez L","Baron O","Africano HF","Bustos IG","Leal R","Ruiz-Cuartas A","Silva E","Beltran CC","Hawkey J"],"additional_accession":[]},"is_claimable":false,"name":"Molecular characterization and descriptive analysis of carbapenemase-producing Gram-negative rod infections in Bogota, Colombia.","description":"In this study, the genetic differences and clinical impact of the carbapenemase-encoding genes among the community and healthcare-acquired infections were assessed. This retrospective, multicenter cohort study was conducted in Colombia and included patients infected with carbapenem-resistant Gram-negative rods between 2017 and 2021. Carbapenem resistance was identified by Vitek, and carbapenemase-encoding genes were identified by whole-genome sequencing (WGS) to classify the alleles and sequence types (STs). Descriptive statistics were used to determine the association of any pathogen or gene with clinical outcomes. A total of 248 patients were included, of which only 0.8% (2/248) had community-acquired infections. Regarding the identified bacteria, the most prevalent pathogens were <i>Pse","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-04T03:24:42.845Z","creation":"2025-04-04T03:24:42.845Z"},"accession":"S-EPMC11237484","cross_references":{"pubmed":["38629835"],"doi":["10.1128/spectrum.01714-23"]}}