biostudies-literatureIbanez-Prada EDUniversidad de La SabanaUniversidad de La Sabana (University of La Sabana)MSD Colombiae0171423https://www.ebi.ac.uk/biostudies/studies/S-EPMC11237484biostudies-literatureUnknown12(6)In this study, the genetic differences and clinical impact of the carbapenemase-encoding genes among the community and healthcare-acquired infections were assessed. This retrospective, multicenter cohort study was conducted in Colombia and included patients infected with carbapenem-resistant Gram-negative rods between 2017 and 2021. Carbapenem resistance was identified by Vitek, and carbapenemase-encoding genes were identified by whole-genome sequencing (WGS) to classify the alleles and sequence types (STs). Descriptive statistics were used to determine the association of any pathogen or gene with clinical outcomes. A total of 248 patients were included, of which only 0.8% (2/248) had community-acquired infections. Regarding the identified bacteria, the most prevalent pathogens were <i>PseMicrobiology spectrumMolecular characterization and descriptive analysis of carbapenemase-producing Gram-negative rod infections in Bogota, Colombia.PMC11237484001MED-315-2021Fuentes YVWyres KLSerrano-Mayorga CCMedina SStewardson AJReyes LFGamboa-Silva EJudd LMJosa DFIbanez-Prada EDHarshegyi TUrrego-Reyes JMendez LBaron OAfricano HFBustos IGLeal RRuiz-Cuartas ASilva EBeltran CCHawkey JfalseMolecular characterization and descriptive analysis of carbapenemase-producing Gram-negative rod infections in Bogota, Colombia.In this study, the genetic differences and clinical impact of the carbapenemase-encoding genes among the community and healthcare-acquired infections were assessed. This retrospective, multicenter cohort study was conducted in Colombia and included patients infected with carbapenem-resistant Gram-negative rods between 2017 and 2021. Carbapenem resistance was identified by Vitek, and carbapenemase-encoding genes were identified by whole-genome sequencing (WGS) to classify the alleles and sequence types (STs). Descriptive statistics were used to determine the association of any pathogen or gene with clinical outcomes. A total of 248 patients were included, of which only 0.8% (2/248) had community-acquired infections. Regarding the identified bacteria, the most prevalent pathogens were <i>Pse2024-01-01T00:00:00Z2024 Jun2025-04-04T03:24:42.845Z2025-04-04T03:24:42.845ZS-EPMC112374843862983510.1128/spectrum.01714-23