{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saeed N"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","Deutsche Forschungsgemeinschaft"],"pagination":["e0034224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11237637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(6)"],"pubmed_abstract":["Amoebae are environmental predators feeding on bacteria, fungi, and other eukaryotic microbes. Predatory interactions alter microbial communities and impose selective pressure toward phagocytic resistance or escape which may, in turn, foster virulence attributes. The ubiquitous fungivorous amoeba <i>Protostelium aurantium</i> has a wide prey spectrum in the fungal kingdom but discriminates against members of the <i>Saccharomyces</i> clade, such as <i>Saccharomyces cerevisiae</i> and <i>Candida glabrata</i>. Here, we show that this prey discrimination among fungi is solely based on the presence of ubiquinone as an essential cofactor for the predator. While the amoeba readily fed on fungi with CoQ presenting longer isoprenyl side chain variants CoQ8-10, such as those from the <i>Candida</i> "],"journal":["mBio"],"pubmed_title":["The isoprenyl chain length of coenzyme Q mediates the nutritional resistance of fungi to amoeba predation."],"pmcid":["PMC11237637"],"funding_grant_id":["HI 1574/4-1"],"pubmed_authors":["Kufs JE","Saeed N","Valiante V","Hillmann F"],"additional_accession":[]},"is_claimable":false,"name":"The isoprenyl chain length of coenzyme Q mediates the nutritional resistance of fungi to amoeba predation.","description":"Amoebae are environmental predators feeding on bacteria, fungi, and other eukaryotic microbes. Predatory interactions alter microbial communities and impose selective pressure toward phagocytic resistance or escape which may, in turn, foster virulence attributes. The ubiquitous fungivorous amoeba <i>Protostelium aurantium</i> has a wide prey spectrum in the fungal kingdom but discriminates against members of the <i>Saccharomyces</i> clade, such as <i>Saccharomyces cerevisiae</i> and <i>Candida glabrata</i>. Here, we show that this prey discrimination among fungi is solely based on the presence of ubiquinone as an essential cofactor for the predator. While the amoeba readily fed on fungi with CoQ presenting longer isoprenyl side chain variants CoQ8-10, such as those from the <i>Candida</i> ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-04-29T12:01:52.005Z","creation":"2025-07-24T03:05:03.321Z"},"accession":"S-EPMC11237637","cross_references":{"pubmed":["38747615"],"doi":["10.1128/mbio.00342-24"]}}