{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Delic S"],"funding":["NIGMS NIH HHS"],"pagination":["1406966"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11238149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Septins are a family of membrane-associated cytoskeletal guanine-nucleotide binding proteins that play crucial roles in various cellular processes, such as cell division, phagocytosis, and organelle fission. Despite their importance, the evolutionary origins and ancestral function of septins remain unclear. In opisthokonts, septins form five distinct groups of orthologs, with subunits from multiple groups assembling into heteropolymers, thus supporting their diverse molecular functions. Recent studies have revealed that septins are also conserved in algae and protists, indicating an ancient origin from the last eukaryotic common ancestor. However, the phylogenetic relationships among septins across eukaryotes remained unclear. Here, we expanded the list of non-opisthokont septins, includin"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["The evolutionary origins and ancestral features of septins."],"pmcid":["PMC11238149"],"funding_grant_id":["R01 GM131004","T32 GM142605"],"pubmed_authors":["Lee S","Shuman B","Bahmanyar S","Momany M","Onishi M","Delic S"],"additional_accession":[]},"is_claimable":false,"name":"The evolutionary origins and ancestral features of septins.","description":"Septins are a family of membrane-associated cytoskeletal guanine-nucleotide binding proteins that play crucial roles in various cellular processes, such as cell division, phagocytosis, and organelle fission. Despite their importance, the evolutionary origins and ancestral function of septins remain unclear. In opisthokonts, septins form five distinct groups of orthologs, with subunits from multiple groups assembling into heteropolymers, thus supporting their diverse molecular functions. Recent studies have revealed that septins are also conserved in algae and protists, indicating an ancient origin from the last eukaryotic common ancestor. However, the phylogenetic relationships among septins across eukaryotes remained unclear. Here, we expanded the list of non-opisthokont septins, includin","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T13:30:44.489Z","creation":"2025-04-05T15:47:53.19Z"},"accession":"S-EPMC11238149","cross_references":{"pubmed":["38994454"],"doi":["10.3389/fcell.2024.1406966"]}}