biostudies-literatureKoyuncu DHHS | National Institutes of HealthNCATS NIH HHSAmerican Lung Association Biomedical Research GrantHHS | National Institutes of Health (NIH)NIAID NIH HHSNHLBI NIH HHSNCI NIH HHSe0026323https://www.ebi.ac.uk/biostudies/studies/S-EPMC11238564biostudies-literatureUnknown92(7)Because most humans resist <i>Mycobacterium tuberculosis</i> infection, there is a paucity of lung samples to study. To address this gap, we infected Diversity Outbred mice with <i>M. tuberculosis</i> and studied the lungs of mice in different disease states. After a low-dose aerosol infection, progressors succumbed to acute, inflammatory lung disease within 60 days, while controllers maintained asymptomatic infection for at least 60 days, and then developed chronic pulmonary tuberculosis (TB) lasting months to more than 1 year. Here, we identified features of asymptomatic <i>M. tuberculosis</i> infection by applying computational and statistical approaches to multimodal data sets. Cytokines and anti-<i>M</i>. <i>tuberculosis</i> cell wall antibodies discriminated progressors vs controllerInfection and immunityB cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic <i>Mycobacterium tuberculosis</i> lung infection in Diversity Outbred mice.PMC11238564P30 CA016058R01 HL145411NIH UL1-TR001430R01 HL126066UL1 TR001430R21 AI115038RG-349504Koyuncu DYener BTavolara TGinese MLSajjad UKramnik INiazi MKKAlsharaydeh ABeamer GGurcan MGower ACGatti DMfalseB cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic <i>Mycobacterium tuberculosis</i> lung infection in Diversity Outbred mice.Because most humans resist <i>Mycobacterium tuberculosis</i> infection, there is a paucity of lung samples to study. To address this gap, we infected Diversity Outbred mice with <i>M. tuberculosis</i> and studied the lungs of mice in different disease states. After a low-dose aerosol infection, progressors succumbed to acute, inflammatory lung disease within 60 days, while controllers maintained asymptomatic infection for at least 60 days, and then developed chronic pulmonary tuberculosis (TB) lasting months to more than 1 year. Here, we identified features of asymptomatic <i>M. tuberculosis</i> infection by applying computational and statistical approaches to multimodal data sets. Cytokines and anti-<i>M</i>. <i>tuberculosis</i> cell wall antibodies discriminated progressors vs controller2024-01-01T00:00:00Z2024 Jul2026-06-01T07:34:30.683Z2025-04-07T12:04:50.376ZS-EPMC112385643889988110.1128/iai.00263-23