biostudies-literatureReina-Campos MNIDDK NIH HHSNIAID NIH HHSNHLBI NIH HHSNCI NIH HHSNIH HHS179-187https://www.ebi.ac.uk/biostudies/studies/S-EPMC11238873biostudies-literatureUnknown621(7977)Tissue resident memory CD8⁺ T (T_RM) cells offer rapid and long-term protection at sites of reinfection¹. Tumour-infiltrating lymphocytes with characteristics of T_RM cells maintain enhanced effector functions, predict responses to immunotherapy and accompany better prognoses^2,3. Thus, an improved understanding of the metabolic strategies that enable tissue residency by T cells could inform new approaches to empower immune responses in tissues and solid tumours. Here, to systematically define the basis for the metabolic reprogramming supporting T_RM cell differentiation, survival and function, we leveraged in vivo functional genomics, untargeted metabolomics and transcriptomics of virus-specific memory CD8⁺ T cell poNatureMetabolic programs of T cell tissue residency empower tumour immunity.PMC11238873P01 AI132122P30 DK063720R01 HL157710R01 AI150282S10 OD021815R01 AI067545P30 CA030199R37 AI067545R01 CA197363R37 AI052116P01 HL146358P30 CA014195R01 CA256133S10 OD026929R01 AI072117Mathews ITSharma SLuna VHuang HJain MNguyen QKrummel MFGoldrath AWChi HKennewick KChang JTVichaidit ABoland BSBensinger SJReina-Campos MHeeg MSantillano NGalletti GHu KHMilner JJfalseMetabolic programs of T cell tissue residency empower tumour immunity.Tissue resident memory CD8⁺ T (T_RM) cells offer rapid and long-term protection at sites of reinfection¹. Tumour-infiltrating lymphocytes with characteristics of T_RM cells maintain enhanced effector functions, predict responses to immunotherapy and accompany better prognoses^2,3. Thus, an improved understanding of the metabolic strategies that enable tissue residency by T cells could inform new approaches to empower immune responses in tissues and solid tumours. Here, to systematically define the basis for the metabolic reprogramming supporting T_RM cell differentiation, survival and function, we leveraged in vivo functional genomics, untargeted metabolomics and transcriptomics of virus-specific memory CD8⁺ T cell po2023-01-01T00:00:00Z2023 Sep2026-04-08T18:40:26.395Z2025-04-07T12:06:14.131ZS-EPMC112388733764885710.1038/s41586-023-06483-w