biostudies-literatureKelly NKNIAID NIH HHS1543-1552https://www.ebi.ac.uk/biostudies/studies/S-EPMC11239282biostudies-literatureUnknown38(10)<h4>Objective</h4>The aim of this study was to estimate the longitudinal associations of state-level anti-LGBTQ+ policies and county-level politics with individual HIV prevention outcomes among sexual and gender minoritized (SGM) youth.<h4>Design</h4>Keeping it LITE-1 prospectively enrolled 3330 SGM youth and young adults (ages 13-34) at increased risk of HIV throughout the United States from 2017 to 2022.<h4>Methods</h4>Semiannual surveys collected self-reported HIV prevention measures [current preexposure prophylaxis (PrEP) use, weekly PrEP adherence, HIV/STI testing in the past 6 months]. Geolocation was linked with state-level LGBTQ+ policy data and county-level election data. Generalized linear models with GEE estimated the single and joint longitudinal associations for two exposures AIDS (London, England)The relationship between anti-LGBTQ+ legislation and HIV prevention among sexual and gender minoritized youth.PMC11239282UH3 AI133676T32 AI070114UG3 AI169631UG3 AI133676Pence BWSlaughter-Acey JPettifor AEFrench ALRanapurwala SIHosek SKelly NKHightow-Weidman LBfalseThe relationship between anti-LGBTQ+ legislation and HIV prevention among sexual and gender minoritized youth.<h4>Objective</h4>The aim of this study was to estimate the longitudinal associations of state-level anti-LGBTQ+ policies and county-level politics with individual HIV prevention outcomes among sexual and gender minoritized (SGM) youth.<h4>Design</h4>Keeping it LITE-1 prospectively enrolled 3330 SGM youth and young adults (ages 13-34) at increased risk of HIV throughout the United States from 2017 to 2022.<h4>Methods</h4>Semiannual surveys collected self-reported HIV prevention measures [current preexposure prophylaxis (PrEP) use, weekly PrEP adherence, HIV/STI testing in the past 6 months]. Geolocation was linked with state-level LGBTQ+ policy data and county-level election data. Generalized linear models with GEE estimated the single and joint longitudinal associations for two exposures 2024-01-01T00:00:00Z2024 Aug2026-03-17T15:29:55.624Z2025-08-16T03:06:56.799ZS-EPMC112392823874288210.1097/qad.000000000000392610.1097/QAD.0000000000003926