{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Fan XY"],"pubmed_abstract":["Tigecycline serves as a last-resort antimicrobial agent against severe infections caused by multidrug-resistant bacteria. Tet(X) and its numerous variants encoding flavin-dependent monooxygenase can confer resistance to tigecycline, with <i>tet</i>(X4) being the most prevalent variant. This study aims to investigate the prevalence and characterize tigecycline resistance gene <i>tet</i>(X) in <i>E. coli</i> isolates from various origins in Yangzhou, China, to provide insights into <i>tet</i>(X) dissemination in this region. In 2022, we tested the presence of <i>tet</i>(X) in 618 <i>E. coli</i> isolates collected from diverse sources, including patients, pig-related samples, chicken-related samples, and vegetables in Yangzhou, China. The antimicrobial susceptibility of <i>tet</i>(X)-positive"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1399732"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11239352"],"repository":["biostudies-literature"],"pubmed_title":["Distribution and spread of tigecycline resistance gene <i>tet</i>(X4) in <i>Escherichia coli</i> from different sources."],"pmcid":["PMC11239352"],"pubmed_authors":["Jiang Y","Sun L","Fan XY","Liu J","Gu QY","Li Q","Wang ZY","Wang J","Jiao X","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Distribution and spread of tigecycline resistance gene <i>tet</i>(X4) in <i>Escherichia coli</i> from different sources.","description":"Tigecycline serves as a last-resort antimicrobial agent against severe infections caused by multidrug-resistant bacteria. Tet(X) and its numerous variants encoding flavin-dependent monooxygenase can confer resistance to tigecycline, with <i>tet</i>(X4) being the most prevalent variant. This study aims to investigate the prevalence and characterize tigecycline resistance gene <i>tet</i>(X) in <i>E. coli</i> isolates from various origins in Yangzhou, China, to provide insights into <i>tet</i>(X) dissemination in this region. In 2022, we tested the presence of <i>tet</i>(X) in 618 <i>E. coli</i> isolates collected from diverse sources, including patients, pig-related samples, chicken-related samples, and vegetables in Yangzhou, China. The antimicrobial susceptibility of <i>tet</i>(X)-positive","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-02T09:30:35.109Z","creation":"2025-07-24T03:05:02.458Z"},"accession":"S-EPMC11239352","cross_references":{"pubmed":["39006743"],"doi":["10.3389/fcimb.2024.1399732"]}}