biostudies-literatureUnknown14Fan XYTigecycline serves as a last-resort antimicrobial agent against severe infections caused by multidrug-resistant bacteria. Tet(X) and its numerous variants encoding flavin-dependent monooxygenase can confer resistance to tigecycline, with <i>tet</i>(X4) being the most prevalent variant. This study aims to investigate the prevalence and characterize tigecycline resistance gene <i>tet</i>(X) in <i>E. coli</i> isolates from various origins in Yangzhou, China, to provide insights into <i>tet</i>(X) dissemination in this region. In 2022, we tested the presence of <i>tet</i>(X) in 618 <i>E. coli</i> isolates collected from diverse sources, including patients, pig-related samples, chicken-related samples, and vegetables in Yangzhou, China. The antimicrobial susceptibility of <i>tet</i>(X)-positiveFrontiers in cellular and infection microbiology1399732https://www.ebi.ac.uk/biostudies/studies/S-EPMC11239352biostudies-literatureDistribution and spread of tigecycline resistance gene <i>tet</i>(X4) in <i>Escherichia coli</i> from different sources.PMC11239352Jiang YSun LFan XYLiu JGu QYLi QWang ZYWang JJiao XWu HfalseDistribution and spread of tigecycline resistance gene <i>tet</i>(X4) in <i>Escherichia coli</i> from different sources.Tigecycline serves as a last-resort antimicrobial agent against severe infections caused by multidrug-resistant bacteria. Tet(X) and its numerous variants encoding flavin-dependent monooxygenase can confer resistance to tigecycline, with <i>tet</i>(X4) being the most prevalent variant. This study aims to investigate the prevalence and characterize tigecycline resistance gene <i>tet</i>(X) in <i>E. coli</i> isolates from various origins in Yangzhou, China, to provide insights into <i>tet</i>(X) dissemination in this region. In 2022, we tested the presence of <i>tet</i>(X) in 618 <i>E. coli</i> isolates collected from diverse sources, including patients, pig-related samples, chicken-related samples, and vegetables in Yangzhou, China. The antimicrobial susceptibility of <i>tet</i>(X)-positive2024-01-01T00:00:00Z20242026-06-02T09:30:35.109Z2025-07-24T03:05:02.458ZS-EPMC112393523900674310.3389/fcimb.2024.1399732