{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Millard SJ"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)","NIDA NIH HHS","NIMH NIH HHS","Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","Brain and Behavior Research Foundation","National Science Foundation (NSF)","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","National Science Foundation"],"pagination":["1253-1259"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11239488"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(7)"],"pubmed_abstract":["Dopamine neurons in the ventral tegmental area support intracranial self-stimulation (ICSS), yet the cognitive representations underlying this phenomenon remain unclear. Here, 20-Hz stimulation of dopamine neurons, which approximates a physiologically relevant prediction error, was not sufficient to support ICSS beyond a continuously reinforced schedule and did not endow cues with a general or specific value. However, 50-Hz stimulation of dopamine neurons was sufficient to drive robust ICSS and was represented as a specific reward to motivate behavior. The frequency dependence of this effect is due to the rate (not the number) of action potentials produced by dopamine neurons, which differently modulates dopamine release downstream."],"journal":["Nature neuroscience"],"pubmed_title":["Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency."],"pmcid":["PMC11239488"],"funding_grant_id":["R01 DA054967","T32 DA055569","R21 MH126278","NIDA R01 057084","R00 DA045765","R21MH126278","R00 DA043572","R00 DA045764","K99 DA043572","R01 DA057084","K99 DA045764","NSF2143910","BBRF 30637","NIDA R01 054967"],"pubmed_authors":["Greer Z","Wassum KM","James MH","Millard SJ","O'Connor SL","Sharpe MJ","Taira M","Barker DJ","Sherwood S","Reyes V","Hoang IB"],"additional_accession":[]},"is_claimable":false,"name":"Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency.","description":"Dopamine neurons in the ventral tegmental area support intracranial self-stimulation (ICSS), yet the cognitive representations underlying this phenomenon remain unclear. Here, 20-Hz stimulation of dopamine neurons, which approximates a physiologically relevant prediction error, was not sufficient to support ICSS beyond a continuously reinforced schedule and did not endow cues with a general or specific value. However, 50-Hz stimulation of dopamine neurons was sufficient to drive robust ICSS and was represented as a specific reward to motivate behavior. The frequency dependence of this effect is due to the rate (not the number) of action potentials produced by dopamine neurons, which differently modulates dopamine release downstream.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-05T15:47:14.758Z","creation":"2025-04-05T15:47:14.758Z"},"accession":"S-EPMC11239488","cross_references":{"pubmed":["38741021"],"doi":["10.1038/s41593-024-01643-1"]}}