{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Steinhoff JS"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","Bundesministerium für Bildung und Forschung","Austrian Science Fund FWF","CSC | Chinese Government Scholarship","Deutsche Forschungsgemeinschaft","Sonnenfeld Stiftung","Bundesministerium für Bildung und Forschung (BMBF)"],"pagination":["2878-2895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11239848"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(7)"],"pubmed_abstract":["Vitamin A (retinol) is distributed via the blood bound to its specific carrier protein, retinol-binding protein 4 (RBP4). Retinol-loaded RBP4 is secreted into the circulation exclusively from hepatocytes, thereby mobilizing hepatic retinoid stores that represent the major vitamin A reserves in the body. The relevance of extrahepatic retinoid stores for circulating retinol and RBP4 levels that are usually kept within narrow physiological limits is unknown. Here, we show that fasting affects retinoid mobilization in a tissue-specific manner, and that hormone-sensitive lipase (HSL) in adipose tissue is required to maintain serum concentrations of retinol and RBP4 during fasting in mice. We found that extracellular retinol-free apo-RBP4 induces retinol release by adipocytes in an HSL-dependent"],"journal":["EMBO reports"],"pubmed_title":["Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting."],"pmcid":["PMC11239848"],"funding_grant_id":["2546/8-1","WO 2624/1-1","10.55776/P34899","10.55776/I3535","SCHU 2546/7-1","01EA1706","SCHU 2546/5-1"],"pubmed_authors":["Wagner C","Kiefer MF","Li C","Yang N","Raila J","Wulff S","Flores RE","Lass A","Meng Y","Guillou H","Schupp M","Taschler U","Schoiswohl G","Kosic K","Petricek KM","Pajed L","Dittrich S","Sommerfeld M","Henze A","Steinhoff JS","Dahnhardt HE","Wowro SJ"],"additional_accession":[]},"is_claimable":false,"name":"Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting.","description":"Vitamin A (retinol) is distributed via the blood bound to its specific carrier protein, retinol-binding protein 4 (RBP4). Retinol-loaded RBP4 is secreted into the circulation exclusively from hepatocytes, thereby mobilizing hepatic retinoid stores that represent the major vitamin A reserves in the body. The relevance of extrahepatic retinoid stores for circulating retinol and RBP4 levels that are usually kept within narrow physiological limits is unknown. Here, we show that fasting affects retinoid mobilization in a tissue-specific manner, and that hormone-sensitive lipase (HSL) in adipose tissue is required to maintain serum concentrations of retinol and RBP4 during fasting in mice. We found that extracellular retinol-free apo-RBP4 induces retinol release by adipocytes in an HSL-dependent","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-27T00:54:21.221Z","creation":"2025-04-06T18:05:59.939Z"},"accession":"S-EPMC11239848","cross_references":{"pubmed":["38769419"],"doi":["10.1038/s44319-024-00158-x"]}}