biostudies-literatureZhou ZSUMC Start-up FundingMOST | National Key Research and Development Program of China (NKPs)MOST | National Key Research and Development Program of ChinaMOST | National Natural Science Foundation of China (NSFC)MOST | National Natural Science Foundation of China2861-2877https://www.ebi.ac.uk/biostudies/studies/S-EPMC11239855biostudies-literatureUnknown25(7)In developing olfactory bulb (OB), mitral cells (MCs) remodel their dendrites to establish the precise olfactory circuit, and these circuits are critical for individuals to sense odors and elicit behaviors for survival. However, how microtubules (MTs) participate in the process of dendritic remodeling remains elusive. Here, we reveal that calmodulin-regulated spectrin-associated proteins (CAMSAPs), a family of proteins that bind to the minus-end of the noncentrosomal MTs, play a crucial part in the development of MC dendrites. We observed that Camsap2 knockout (KO) males are infertile while the reproductive tract is normal. Further study showed that the infertility was due to the severe defects of mating behavior in male mice. Besides, mice with loss-of-function displayed defects in the seEMBO reportsDeficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells.PMC11239855510858072321007602018YFA08011042021YFA08048023227073631930025Lin RShao JXu PHu WYang MXu HXie QZhang RZhou ZMeng WYang XLi WLi YLin CMao AXu ZfalseDeficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells.In developing olfactory bulb (OB), mitral cells (MCs) remodel their dendrites to establish the precise olfactory circuit, and these circuits are critical for individuals to sense odors and elicit behaviors for survival. However, how microtubules (MTs) participate in the process of dendritic remodeling remains elusive. Here, we reveal that calmodulin-regulated spectrin-associated proteins (CAMSAPs), a family of proteins that bind to the minus-end of the noncentrosomal MTs, play a crucial part in the development of MC dendrites. We observed that Camsap2 knockout (KO) males are infertile while the reproductive tract is normal. Further study showed that the infertility was due to the severe defects of mating behavior in male mice. Besides, mice with loss-of-function displayed defects in the se2024-01-01T00:00:00Z2024 Jul2026-06-02T22:04:43.82Z2026-05-28T03:06:24.518ZS-EPMC112398553883994410.1038/s44319-024-00166-x