{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Galanopoulou O"],"funding":["European Research Council","AXA Research Fund (Le Fonds AXA pour la Recherche)"],"pagination":["5843"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11239883"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Setd8 regulates transcription elongation, mitotic DNA condensation, DNA damage response and replication licensing. Here we show that, in mitogen-stimulated liver-specific Setd8-KO mice, most of the hepatocytes are eliminated by necrosis but a significant number of them survive via entering a stage exhibiting several senescence-related features. Setd8-deficient hepatocytes had enlarged nuclei, chromosomal hyperploidy and nuclear engulfments progressing to the formation of intranuclear vesicles surrounded by nuclear lamina. These vesicles contain glycogen, cytoplasmic proteins and even entire organelles. We term this process \"endonucleosis\". Intranuclear vesicles are absent in hepatocytes of Setd8/Atg5 knockout mice, suggesting that the process requires the function of the canonical autophag"],"journal":["Nature communications"],"pubmed_title":["Endonucleosis mediates internalization of cytoplasm into the nucleus."],"pmcid":["PMC11239883"],"funding_grant_id":["#2016","ERC-2011-AdG294464"],"pubmed_authors":["Gargani S","Chalepakis G","Tachmatzidi EC","Galanopoulou O","Deligianni E","Talianidis I","Nikolaou KC","Dalezios Y","Botskaris D"],"additional_accession":[]},"is_claimable":false,"name":"Endonucleosis mediates internalization of cytoplasm into the nucleus.","description":"Setd8 regulates transcription elongation, mitotic DNA condensation, DNA damage response and replication licensing. Here we show that, in mitogen-stimulated liver-specific Setd8-KO mice, most of the hepatocytes are eliminated by necrosis but a significant number of them survive via entering a stage exhibiting several senescence-related features. Setd8-deficient hepatocytes had enlarged nuclei, chromosomal hyperploidy and nuclear engulfments progressing to the formation of intranuclear vesicles surrounded by nuclear lamina. These vesicles contain glycogen, cytoplasmic proteins and even entire organelles. We term this process \"endonucleosis\". Intranuclear vesicles are absent in hepatocytes of Setd8/Atg5 knockout mice, suggesting that the process requires the function of the canonical autophag","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-27T00:55:01.227Z","creation":"2025-04-06T18:05:08.876Z"},"accession":"S-EPMC11239883","cross_references":{"pubmed":["38992049"],"doi":["10.1038/s41467-024-50259-3"]}}