biostudies-literatureUnknown7(7)Johnson LS<h4>Importance</h4>Numerous prospective cohort studies have reported a J-shaped association of urinary sodium excretion with cardiovascular events and mortality.<h4>Objective</h4>To study the association between sodium intake and incident atrial fibrillation (AF).<h4>Design, setting, and participants</h4>This cohort study included participants in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) and Telmisartan Randomised Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease (TRANSCEND) multicenter, randomized clinical trials comparing the effect of ramipril 10 mg daily with telmisartan 80 mg daily, or their combination (ONTARGET) or 80 mg telmisartan daily with placebo (TRANSCEND) for the outcome of death from cardiovascular JAMA network opene2421589https://www.ebi.ac.uk/biostudies/studies/S-EPMC11240191biostudies-literatureSodium Intake and Incident Atrial Fibrillation in Individuals With Vascular Disease.PMC11240191Joseph PMente AConnolly SJConen DYusuf SHealey JSJohnson LSBenz APMcIntyre WFEngstrom GDrake IfalseSodium Intake and Incident Atrial Fibrillation in Individuals With Vascular Disease.<h4>Importance</h4>Numerous prospective cohort studies have reported a J-shaped association of urinary sodium excretion with cardiovascular events and mortality.<h4>Objective</h4>To study the association between sodium intake and incident atrial fibrillation (AF).<h4>Design, setting, and participants</h4>This cohort study included participants in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) and Telmisartan Randomised Assessment Study in ACE Intolerant Subjects With Cardiovascular Disease (TRANSCEND) multicenter, randomized clinical trials comparing the effect of ramipril 10 mg daily with telmisartan 80 mg daily, or their combination (ONTARGET) or 80 mg telmisartan daily with placebo (TRANSCEND) for the outcome of death from cardiovascular 2024-01-01T00:00:00Z2024 Jul2025-04-27T00:55:27.5Z2025-04-06T18:06:20.644ZS-EPMC112401913899056910.1001/jamanetworkopen.2024.21589