{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Deng H"],"pubmed_abstract":["Prolyl hydroxylase domain protein 2 (PHD2) is one of the intracellular oxygen sensors that mediates proteasomal degradation of hypoxia-inducible factor (HIF)-α via hydroxylation under normoxic conditions. Because of its canonical function in the hypoxia signaling pathway, PHD2 is generally regarded as a tumor suppressor. However, the effects of PHD2 in tumorigenesis are not entirely dependent on HIF-α. Based on analysis of data from the Cancer Genome Atlas (TCGA) database, we observed that the expression of <i>PHD2</i> is upregulated in non-small cell lung cancer (NSCLC), which accounts for approximately 80-85% of lung cancers. This suggests that PHD2 may play an important role in NSCLC. However, the function of PHD2 in NSCLC remains largely unknown. In this study, we established <i>PHD2</"],"journal":["Frontiers in oncology"],"pagination":["1370393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11240288"],"repository":["biostudies-literature"],"pubmed_title":["Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners."],"pmcid":["PMC11240288"],"pubmed_authors":["Chen Z","Wang Z","Deng H","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners.","description":"Prolyl hydroxylase domain protein 2 (PHD2) is one of the intracellular oxygen sensors that mediates proteasomal degradation of hypoxia-inducible factor (HIF)-α via hydroxylation under normoxic conditions. Because of its canonical function in the hypoxia signaling pathway, PHD2 is generally regarded as a tumor suppressor. However, the effects of PHD2 in tumorigenesis are not entirely dependent on HIF-α. Based on analysis of data from the Cancer Genome Atlas (TCGA) database, we observed that the expression of <i>PHD2</i> is upregulated in non-small cell lung cancer (NSCLC), which accounts for approximately 80-85% of lung cancers. This suggests that PHD2 may play an important role in NSCLC. However, the function of PHD2 in NSCLC remains largely unknown. In this study, we established <i>PHD2</","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T07:14:54.526Z","creation":"2026-04-08T10:17:45.066Z"},"accession":"S-EPMC11240288","cross_references":{"pubmed":["39007099"],"doi":["10.3389/fonc.2024.1370393"]}}