{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gao Z"],"funding":["the Special Construction Project Fund for Shandong Province Taishan Scholars","Shandong Province Natural Science Foundation","the Support Plan on Science and Technology for Youth Innovation of Universities in Shandong Province","Guangyue Young Scholar Innovation Team Foundation of Liaocheng University","the National Natural Science Foundation of China"],"pagination":["6916"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11241244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(13)"],"pubmed_abstract":["3,4-disubstituted maleimides find wide applications in various pharmacologically active compounds. This study presents a highly effective approach for synthesizing derivatives of 3,4-disubstituted maleimides through the direct isomerization of α-succinimide-substituted allenoates, followed by a cascade γ'-addition and aryl imines using PR<sub>3</sub> as a catalyst. The resulting series of 3,4-disubstituted maleimides exhibited excellent stereoselectivities, achieving yields of up to 86%. To our knowledge, the phosphine-mediated γ'-addition reaction of allenoates is seldom reported."],"journal":["International journal of molecular sciences"],"pubmed_title":["Synthesis of 3,4-Disubstituted Maleimide Derivatives via Phosphine-Catalyzed Isomerization of α-Succinimide-Substituted Allenoates Cascade γ'-Addition with Aryl Imines."],"pmcid":["PMC11241244"],"funding_grant_id":["no","ZR2021MB110","LCUGYTD2022-04","No. 22101002","2022KJ111"],"pubmed_authors":["Nie B","Wu J","Lu H","Gao Z","Chen X","Wang X","Zhou X","Li L"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of 3,4-Disubstituted Maleimide Derivatives via Phosphine-Catalyzed Isomerization of α-Succinimide-Substituted Allenoates Cascade γ'-Addition with Aryl Imines.","description":"3,4-disubstituted maleimides find wide applications in various pharmacologically active compounds. This study presents a highly effective approach for synthesizing derivatives of 3,4-disubstituted maleimides through the direct isomerization of α-succinimide-substituted allenoates, followed by a cascade γ'-addition and aryl imines using PR<sub>3</sub> as a catalyst. The resulting series of 3,4-disubstituted maleimides exhibited excellent stereoselectivities, achieving yields of up to 86%. To our knowledge, the phosphine-mediated γ'-addition reaction of allenoates is seldom reported.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-04-08T15:18:44.344Z","creation":"2025-04-04T08:04:09.966Z"},"accession":"S-EPMC11241244","cross_references":{"pubmed":["39000025"],"doi":["10.3390/ijms25136916"]}}