{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roman-Saguillo S"],"funding":["The Ministerio de Educación","Ministerio de Ciencia, Innovación y Universidades","Finance the Predoctoral Recruitment of Research Personnel by the Junta de Castilla y Leon","Junta de Castilla y León and the European Regional Development Fund","Ministerio de Ciencia e Innovación","Instituto de Salud Carlos III (ISCIII)"],"pagination":["6863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11241776"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(13)"],"pubmed_abstract":["Several hepatic disorders are influenced by gut microbiota, but its role in idiosyncratic drug-induced liver injury (iDILI), whose main causative agent is amoxicillin-clavulanate, remains unknown. This pioneering study aims to unravel particular patterns of gut microbiota composition and associated metabolites in iDILI and iDILI patients by amoxicillin-clavulanate (iDILI-AC). Thus, serum and fecal samples from 46 patients were divided into three study groups: healthy controls (n = 10), non-iDILI acute hepatitis (n = 12) and iDILI patients (n = 24). To evaluate the amoxicillin-clavulanate effect, iDILI patients were separated into two subgroups: iDILI non-caused by amoxicillin-clavulanate (iDILI-nonAC) (n = 18) and iDILI-AC patients (n = 6). Gut microbiota composition and fecal metabolome p"],"journal":["International journal of molecular sciences"],"pubmed_title":["Idiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients."],"pmcid":["PMC11241776"],"funding_grant_id":["GRS2126/A/2020","LE017-P20","FPU18/06257","PI20/00690","PID2020-120363RB-I00"],"pubmed_authors":["Gonzalez-Gallego J","Robles-Diaz M","Garcia-Mediavilla MV","Stephens C","Juarez-Fernandez M","Jorquera Plaza F","Jover R","Sanchez-Campos S","Martinez-Florez S","Quinones Castro R","Nistal E","Soluyanova P","Roman-Saguillo S"],"additional_accession":[]},"is_claimable":false,"name":"Idiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients.","description":"Several hepatic disorders are influenced by gut microbiota, but its role in idiosyncratic drug-induced liver injury (iDILI), whose main causative agent is amoxicillin-clavulanate, remains unknown. This pioneering study aims to unravel particular patterns of gut microbiota composition and associated metabolites in iDILI and iDILI patients by amoxicillin-clavulanate (iDILI-AC). Thus, serum and fecal samples from 46 patients were divided into three study groups: healthy controls (n = 10), non-iDILI acute hepatitis (n = 12) and iDILI patients (n = 24). To evaluate the amoxicillin-clavulanate effect, iDILI patients were separated into two subgroups: iDILI non-caused by amoxicillin-clavulanate (iDILI-nonAC) (n = 18) and iDILI-AC patients (n = 6). Gut microbiota composition and fecal metabolome p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-07-09T11:09:35.752Z","creation":"2026-07-09T10:41:35.4Z"},"accession":"S-EPMC11241776","cross_references":{"pubmed":["38999973"],"doi":["10.3390/ijms25136863"]}}