biostudies-literatureRoman-Saguillo SThe Ministerio de EducaciónMinisterio de Ciencia, Innovación y UniversidadesFinance the Predoctoral Recruitment of Research Personnel by the Junta de Castilla y LeonJunta de Castilla y León and the European Regional Development FundMinisterio de Ciencia e InnovaciónInstituto de Salud Carlos III (ISCIII)6863https://www.ebi.ac.uk/biostudies/studies/S-EPMC11241776biostudies-literatureUnknown25(13)Several hepatic disorders are influenced by gut microbiota, but its role in idiosyncratic drug-induced liver injury (iDILI), whose main causative agent is amoxicillin-clavulanate, remains unknown. This pioneering study aims to unravel particular patterns of gut microbiota composition and associated metabolites in iDILI and iDILI patients by amoxicillin-clavulanate (iDILI-AC). Thus, serum and fecal samples from 46 patients were divided into three study groups: healthy controls (n = 10), non-iDILI acute hepatitis (n = 12) and iDILI patients (n = 24). To evaluate the amoxicillin-clavulanate effect, iDILI patients were separated into two subgroups: iDILI non-caused by amoxicillin-clavulanate (iDILI-nonAC) (n = 18) and iDILI-AC patients (n = 6). Gut microbiota composition and fecal metabolome pInternational journal of molecular sciencesIdiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients.PMC11241776GRS2126/A/2020LE017-P20FPU18/06257PI20/00690PID2020-120363RB-I00Gonzalez-Gallego JRobles-Diaz MGarcia-Mediavilla MVStephens CJuarez-Fernandez MJorquera Plaza FJover RSanchez-Campos SMartinez-Florez SQuinones Castro RNistal ESoluyanova PRoman-Saguillo SfalseIdiosyncratic Drug-Induced Liver Injury and Amoxicillin-Clavulanate: Spotlight on Gut Microbiota, Fecal Metabolome and Bile Acid Profile in Patients.Several hepatic disorders are influenced by gut microbiota, but its role in idiosyncratic drug-induced liver injury (iDILI), whose main causative agent is amoxicillin-clavulanate, remains unknown. This pioneering study aims to unravel particular patterns of gut microbiota composition and associated metabolites in iDILI and iDILI patients by amoxicillin-clavulanate (iDILI-AC). Thus, serum and fecal samples from 46 patients were divided into three study groups: healthy controls (n = 10), non-iDILI acute hepatitis (n = 12) and iDILI patients (n = 24). To evaluate the amoxicillin-clavulanate effect, iDILI patients were separated into two subgroups: iDILI non-caused by amoxicillin-clavulanate (iDILI-nonAC) (n = 18) and iDILI-AC patients (n = 6). Gut microbiota composition and fecal metabolome p2024-01-01T00:00:00Z2024 Jun2026-07-09T11:09:35.752Z2026-07-09T10:41:35.4ZS-EPMC112417763899997310.3390/ijms25136863