{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xue Y"],"funding":["National Key Research and Development Program of China"],"pagination":["6947"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11241798"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(13)"],"pubmed_abstract":["<i>Toxoplasma gondii</i>, an important opportunistic pathogen, underscores the necessity of developing novel therapeutic drugs and identifying new drug targets. Our findings indicate that the half-maximal inhibitory concentrations (IC<sub>50</sub>) of KU60019 and CP466722 (abbreviated as KU and CP) against <i>T. gondii</i> are 0.522 μM and 0.702 μM, respectively, with selection indices (SI) of 68 and 10. Treatment with KU and CP affects the in vitro growth of <i>T. gondii</i>, inducing aberrant division in the daughter parasites. Transmission electron microscopy reveals that KU and CP prompt the anomalous division of <i>T. gondii</i>, accompanied by cellular enlargement, nuclear shrinkage, and an increased dense granule density, suggesting potential damage to parasite vesicle transport. Su"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Effects and Mechanism of ATM Kinase Inhibitors in <i>Toxoplasma gondii</i>."],"pmcid":["PMC11241798"],"funding_grant_id":["2023YFD1802400"],"pubmed_authors":["Liu J","Ying Z","Wang F","Liu Q","Pei Y","Yin M","Xue Y"],"additional_accession":[]},"is_claimable":false,"name":"The Effects and Mechanism of ATM Kinase Inhibitors in <i>Toxoplasma gondii</i>.","description":"<i>Toxoplasma gondii</i>, an important opportunistic pathogen, underscores the necessity of developing novel therapeutic drugs and identifying new drug targets. Our findings indicate that the half-maximal inhibitory concentrations (IC<sub>50</sub>) of KU60019 and CP466722 (abbreviated as KU and CP) against <i>T. gondii</i> are 0.522 μM and 0.702 μM, respectively, with selection indices (SI) of 68 and 10. Treatment with KU and CP affects the in vitro growth of <i>T. gondii</i>, inducing aberrant division in the daughter parasites. Transmission electron microscopy reveals that KU and CP prompt the anomalous division of <i>T. gondii</i>, accompanied by cellular enlargement, nuclear shrinkage, and an increased dense granule density, suggesting potential damage to parasite vesicle transport. Su","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-04-20T03:23:21.58Z","creation":"2026-04-20T03:14:35.225Z"},"accession":"S-EPMC11241798","cross_references":{"pubmed":["39000057"],"doi":["10.3390/ijms25136947"]}}