{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["the Foundation of National Infrastructures for Translational Medicine (Shanghai)","the Foundation of National Infrastructures for Translational Medicine","the National Natural Science Foundation of China","Innovative research team of high-level local universities in Shanghai"],"pagination":["249"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11241881"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Previous studies have shown that peptides encoded by noncoding RNAs (ncRNAs) can be used as peptide drugs to alleviate diseases. We found that microRNA-31 (miR-31) is involved in the regulation of hypertension and that the peptide miPEP31, which is encoded by the primary transcript of miR-31 (pri-miR-31), can inhibit miR-31 expression. However, the role and mechanism of miPEP31 in hypertension have not been elucidated.<h4>Methods</h4>miPEP31 expression was determined by western blot analysis. miPEP31-deficient mice (miPEP31<sup>-/-</sup>) were used, and synthetic miPEP31 was injected into Ang II-induced hypertensive mice. Blood pressure was monitored through the tail-cuff method. Histological staining was used to evaluate renal damage. Regulatory T (T<sub>reg</sub>) cell"],"journal":["Cardiovascular diabetology"],"pubmed_title":["miPEP31 alleviates Ang II-induced hypertension in mice by occupying Cebpα binding sites in the pri-miR-31 promoter."],"pmcid":["PMC11241881"],"funding_grant_id":["82070509","SHSMU-ZDCX20212700","82370902","82101909","TMSK-2021-506"],"pubmed_authors":["Tian J","Li X","Fang Z","Jiang G","Chen W","Shi G","Tong X","Li Q","Zhou H","Lu P","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"miPEP31 alleviates Ang II-induced hypertension in mice by occupying Cebpα binding sites in the pri-miR-31 promoter.","description":"<h4>Background</h4>Previous studies have shown that peptides encoded by noncoding RNAs (ncRNAs) can be used as peptide drugs to alleviate diseases. We found that microRNA-31 (miR-31) is involved in the regulation of hypertension and that the peptide miPEP31, which is encoded by the primary transcript of miR-31 (pri-miR-31), can inhibit miR-31 expression. However, the role and mechanism of miPEP31 in hypertension have not been elucidated.<h4>Methods</h4>miPEP31 expression was determined by western blot analysis. miPEP31-deficient mice (miPEP31<sup>-/-</sup>) were used, and synthetic miPEP31 was injected into Ang II-induced hypertensive mice. Blood pressure was monitored through the tail-cuff method. Histological staining was used to evaluate renal damage. Regulatory T (T<sub>reg</sub>) cell","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-27T01:01:44.356Z","creation":"2025-04-06T18:03:56.207Z"},"accession":"S-EPMC11241881","cross_references":{"pubmed":["38992718"],"doi":["10.1186/s12933-024-02337-5"]}}