biostudies-literatureLi Xthe Foundation of National Infrastructures for Translational Medicine (Shanghai)the Foundation of National Infrastructures for Translational Medicinethe National Natural Science Foundation of ChinaInnovative research team of high-level local universities in Shanghai249https://www.ebi.ac.uk/biostudies/studies/S-EPMC11241881biostudies-literatureUnknown23(1)<h4>Background</h4>Previous studies have shown that peptides encoded by noncoding RNAs (ncRNAs) can be used as peptide drugs to alleviate diseases. We found that microRNA-31 (miR-31) is involved in the regulation of hypertension and that the peptide miPEP31, which is encoded by the primary transcript of miR-31 (pri-miR-31), can inhibit miR-31 expression. However, the role and mechanism of miPEP31 in hypertension have not been elucidated.<h4>Methods</h4>miPEP31 expression was determined by western blot analysis. miPEP31-deficient mice (miPEP31^-/-) were used, and synthetic miPEP31 was injected into Ang II-induced hypertensive mice. Blood pressure was monitored through the tail-cuff method. Histological staining was used to evaluate renal damage. Regulatory T (T_reg) cellCardiovascular diabetologymiPEP31 alleviates Ang II-induced hypertension in mice by occupying Cebpα binding sites in the pri-miR-31 promoter.PMC1124188182070509SHSMU-ZDCX202127008237090282101909TMSK-2021-506Tian JLi XFang ZJiang GChen WShi GTong XLi QZhou HLu PZhang PfalsemiPEP31 alleviates Ang II-induced hypertension in mice by occupying Cebpα binding sites in the pri-miR-31 promoter.<h4>Background</h4>Previous studies have shown that peptides encoded by noncoding RNAs (ncRNAs) can be used as peptide drugs to alleviate diseases. We found that microRNA-31 (miR-31) is involved in the regulation of hypertension and that the peptide miPEP31, which is encoded by the primary transcript of miR-31 (pri-miR-31), can inhibit miR-31 expression. However, the role and mechanism of miPEP31 in hypertension have not been elucidated.<h4>Methods</h4>miPEP31 expression was determined by western blot analysis. miPEP31-deficient mice (miPEP31^-/-) were used, and synthetic miPEP31 was injected into Ang II-induced hypertensive mice. Blood pressure was monitored through the tail-cuff method. Histological staining was used to evaluate renal damage. Regulatory T (T_reg) cell2024-01-01T00:00:00Z2024 Jul2025-04-27T01:01:44.356Z2025-04-06T18:03:56.207ZS-EPMC112418813899271810.1186/s12933-024-02337-5