{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jonic N"],"funding":["Serbian Clinical Immunology Fund New Castle, UK","European Regional Development Fund of the European Union","Ministry of Science, Technological Development and Innovations of the Republic of Serbia","Greek national funds","European Union’s Horizon 2020 research and innovation programme","European Regional Development Fund","H2020-WIDESPREAD-2018-951921-ImmunoHUB"],"pagination":["2988"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11243367"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(13)"],"pubmed_abstract":["Aryl Hydrocarbon Receptor (AHR) ligands, upon binding, induce distinct gene expression profiles orchestrated by the AHR, leading to a spectrum of pro- or anti-inflammatory effects. In this study, we designed, synthesized and evaluated three indole-containing potential AHR ligands (FluoAHRL: AGT-4, AGT-5 and AGT-6). All synthesized compounds were shown to emit fluorescence in the near-infrared. Their AHR agonist activity was first predicted using in silico docking studies, and then confirmed using AHR luciferase reporter cell lines. FluoAHRLs were tested in vitro using mouse peritoneal macrophages and T lymphocytes to assess their immunomodulatory properties. We then focused on AGT-5, as it illustrated the predominant anti-inflammatory effects. Notably, AGT-5 demonstrated the ability to fos"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Development of FluoAHRL: A Novel Synthetic Fluorescent Compound That Activates AHR and Potentiates Anti-Inflammatory T Regulatory Cells."],"pmcid":["PMC11243367"],"funding_grant_id":["TAEDK-06189/ Τ2EDK-0326","N/A","451-03-66/2024-03/200007","951921","TAEDK-06189/Τ2EDK-0326"],"pubmed_authors":["Marinho S","Moura-Alves P","Jonic N","Jovanovic MB","Pavic A","Dimitrijevic M","Otasevic V","Kyrkou SG","Castro-Almeida I","Tzakos EP","Koprivica I","Stojanovic I","Chatzigiannis CM","Tzakos AG","Jovanovic A","Tsiailanis AD"],"additional_accession":[]},"is_claimable":false,"name":"Development of FluoAHRL: A Novel Synthetic Fluorescent Compound That Activates AHR and Potentiates Anti-Inflammatory T Regulatory Cells.","description":"Aryl Hydrocarbon Receptor (AHR) ligands, upon binding, induce distinct gene expression profiles orchestrated by the AHR, leading to a spectrum of pro- or anti-inflammatory effects. In this study, we designed, synthesized and evaluated three indole-containing potential AHR ligands (FluoAHRL: AGT-4, AGT-5 and AGT-6). All synthesized compounds were shown to emit fluorescence in the near-infrared. Their AHR agonist activity was first predicted using in silico docking studies, and then confirmed using AHR luciferase reporter cell lines. FluoAHRLs were tested in vitro using mouse peritoneal macrophages and T lymphocytes to assess their immunomodulatory properties. We then focused on AGT-5, as it illustrated the predominant anti-inflammatory effects. Notably, AGT-5 demonstrated the ability to fos","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-05-28T03:08:11.809Z","creation":"2025-04-04T13:41:07.914Z"},"accession":"S-EPMC11243367","cross_references":{"pubmed":["38998940"],"doi":["10.3390/molecules29132988"]}}