{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Gao Y"],"funding":["NCI NIH HHS"],"pubmed_abstract":["Understanding cellular birth rate differences is crucial for predicting cancer progression and interpreting tumor-derived genetic data. Lineage tracing experiments enable detailed reconstruction of cellular genealogies, offering new opportunities to measure branching rate heterogeneity. However, the lineage tracing process can introduce complex tree features that complicate this effort. Here, we examine tree characteristics in lineage tracing-derived genealogies and find that editing window placement leads to multifurcations at a tree's root or tips. We propose several ways in which existing tree topology-based metrics can be extended to test for rate heterogeneity on trees even in the presence of lineage-tracing associated distortions. Although these methods vary in power and robustness, "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.06.27.601073"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11244928"],"repository":["biostudies-literature"],"pubmed_title":["Detecting branching rate heterogeneity in multifurcating trees with applications in lineage tracing data."],"pmcid":["PMC11244928"],"funding_grant_id":["DP2 CA280623"],"pubmed_authors":["Gao Y","Feder AF"],"additional_accession":[]},"is_claimable":false,"name":"Detecting branching rate heterogeneity in multifurcating trees with applications in lineage tracing data.","description":"Understanding cellular birth rate differences is crucial for predicting cancer progression and interpreting tumor-derived genetic data. Lineage tracing experiments enable detailed reconstruction of cellular genealogies, offering new opportunities to measure branching rate heterogeneity. However, the lineage tracing process can introduce complex tree features that complicate this effort. Here, we examine tree characteristics in lineage tracing-derived genealogies and find that editing window placement leads to multifurcations at a tree's root or tips. We propose several ways in which existing tree topology-based metrics can be extended to test for rate heterogeneity on trees even in the presence of lineage-tracing associated distortions. Although these methods vary in power and robustness, ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T10:13:25.259Z","creation":"2025-04-04T10:13:25.259Z"},"accession":"S-EPMC11244928","cross_references":{"pubmed":["39005367"],"doi":["10.1101/2024.06.27.601073"]}}