{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Pires IS"],"funding":["NCI NIH HHS"],"pubmed_abstract":["Immunotherapies such as checkpoint inhibitors (CPI) are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer (OC). Here, we engineered liposomal nanoparticles (NPs) carrying a layer-by-layer (LbL) polymer coating that promotes their binding to the surface of OC cells. Covalent anchoring of the potent immunostimulatory cytokine interleukin-12 (IL-12) to phospholipid headgroups of the liposome core enabled the LbL particles to concentrate IL-12 in disseminated OC tumors following intraperitoneal administration. Shedding of the LbL coating and serum protein-mediated extraction of IL-12-conjugated lipids from the liposomal core over time enabled IL-12 to disseminate in the tumor bed following rapid NP localization in tumor n"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.07.05.602135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11245112"],"repository":["biostudies-literature"],"pubmed_title":["\"Target-and-release\" nanoparticles for effective immunotherapy of metastatic ovarian cancer."],"pmcid":["PMC11245112"],"funding_grant_id":["P30 CA014051","F99 CA274651","R01 CA235375"],"pubmed_authors":["Irvine DJ","Backlund C","Gomerdinger VF","Melo MB","Covarrubias G","Suh H","Shanker A","Wu S","Gordon E","Pires IS","Hammond PT","Pickering AJ"],"additional_accession":[]},"is_claimable":false,"name":"\"Target-and-release\" nanoparticles for effective immunotherapy of metastatic ovarian cancer.","description":"Immunotherapies such as checkpoint inhibitors (CPI) are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer (OC). Here, we engineered liposomal nanoparticles (NPs) carrying a layer-by-layer (LbL) polymer coating that promotes their binding to the surface of OC cells. Covalent anchoring of the potent immunostimulatory cytokine interleukin-12 (IL-12) to phospholipid headgroups of the liposome core enabled the LbL particles to concentrate IL-12 in disseminated OC tumors following intraperitoneal administration. Shedding of the LbL coating and serum protein-mediated extraction of IL-12-conjugated lipids from the liposomal core over time enabled IL-12 to disseminate in the tumor bed following rapid NP localization in tumor n","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-15T03:16:33.547Z","creation":"2025-04-04T01:46:50.65Z"},"accession":"S-EPMC11245112","cross_references":{"pubmed":["39005274"],"doi":["10.1101/2024.07.05.602135"]}}