biostudies-literatureUnknown23(6)O'Neill JRFNPEuropean CommissionEfforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to understand the somatic mutations associated with EAC over the past decade, a gap remains in understanding how the atlas of genomic aberrations in this cancer impacts the proteome and which somatic variants are of importance for the disease phenotype. We performed a quantitative proteomic analysis of 23 EACs and matched adjacent normal esophageal and gastric tissues. We explored the correlation of transcript and protein abundance using tissue-matched RNA-seq and proteomic data from seven patients and further integrated these data with a cohort of EAC RNA-seq data (n = 264 patients), EAMolecular & cellular proteomics : MCP100764https://www.ebi.ac.uk/biostudies/studies/S-EPMC11245951biostudies-literatureMulti-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation.PMC11245951Davies ASafranek PKocikowski MCarroll NLagergren JGoh VUhrik LSaunders JHanna GBContino GHardwick RHLovat LSave VTaniere PLishman SYebenes Mayordomo MMahadeva UDevonshire GNutzinger BSujendran VFaktor JChan DCheong EColeman HSanders GPetty RDArends MJMcManus DGrehan NAng YWalker RCO'Neill JRFreeman ADavies JMitulovic GKaye PGrabowska AMalhotra SO'Donovan MBedran GFitzgerald RCPeters CJLoreno CJammula SHindmarsh AHayes SJRedmond AMScott MSreedharan LMoorthy KSecrier MHernychova LSothi SGossage JGomez-Herranz MBartlet FCrichton CPuig SHupp TRParsons SLChang FHaidry RVojtesek BSkipworth RJEBeggs AUnderwood TJBagwan IHupp TMiremadi AAbbas SBerrisford RTripathi MMillington CSharrocks APreston SRAlfaro JAOCCAMS ConsortiumAl Shboul SGrace BLSoomro ICiccarelli FDColes HEdwards PAWTucker OCheah CTurkington RSmyth ECKumar BEldridge MfalseMulti-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation.Efforts to address the poor prognosis associated with esophageal adenocarcinoma (EAC) have been hampered by a lack of biomarkers to identify early disease and therapeutic targets. Despite extensive efforts to understand the somatic mutations associated with EAC over the past decade, a gap remains in understanding how the atlas of genomic aberrations in this cancer impacts the proteome and which somatic variants are of importance for the disease phenotype. We performed a quantitative proteomic analysis of 23 EACs and matched adjacent normal esophageal and gastric tissues. We explored the correlation of transcript and protein abundance using tissue-matched RNA-seq and proteomic data from seven patients and further integrated these data with a cohort of EAC RNA-seq data (n = 264 patients), EA2024-01-01T00:00:00Z2024 Jun2026-07-15T08:13:14.043Z2025-04-04T08:04:12.362ZS-EPMC112459513860450310.1016/j.mcpro.2024.100764