{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin W"],"funding":["General Research Fund of Shanghai Normal University","University Grants Committee Research Grants Council"],"pagination":["63-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11245956"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47"],"pubmed_abstract":["<h4>Background</h4>The interaction between muscle and bone is shown to be clinically important but the underlying mechanisms are largely unknown. The canonical Wnt/β-catenin signaling pathway is reported to be involved in muscle-bone crosstalk, but its detailed function remains unclear. This systematic review aims to investigate and elucidate the role of the Wnt/β-catenin signaling pathways in muscle-bone crosstalk.<h4>Methods</h4>We conducted a literature search on the Web of Science, PubMed, EBSCO and Embase with keywords \"Wnt*\", \"bone*\" and \"muscle*\". A systematic review was completed according to the guideline of preferred reporting items of systematic reviews and meta-analyses (PRISMA). Data synthesis included species (human, animal or cell type used), treatments involved, outcome mea"],"journal":["Journal of orthopaedic translation"],"pubmed_title":["Wnt/β-catenin signaling pathway as an important mediator in muscle and bone crosstalk: A systematic review."],"pmcid":["PMC11245956"],"funding_grant_id":["14114822","AoE/M-402/20"],"pubmed_authors":["Chow SKH","Wang Q","Wong RMY","Lin W","Zhang N","Liu C","Chai S","Cui C","Cheung WH"],"additional_accession":[]},"is_claimable":false,"name":"Wnt/β-catenin signaling pathway as an important mediator in muscle and bone crosstalk: A systematic review.","description":"<h4>Background</h4>The interaction between muscle and bone is shown to be clinically important but the underlying mechanisms are largely unknown. The canonical Wnt/β-catenin signaling pathway is reported to be involved in muscle-bone crosstalk, but its detailed function remains unclear. This systematic review aims to investigate and elucidate the role of the Wnt/β-catenin signaling pathways in muscle-bone crosstalk.<h4>Methods</h4>We conducted a literature search on the Web of Science, PubMed, EBSCO and Embase with keywords \"Wnt*\", \"bone*\" and \"muscle*\". A systematic review was completed according to the guideline of preferred reporting items of systematic reviews and meta-analyses (PRISMA). Data synthesis included species (human, animal or cell type used), treatments involved, outcome mea","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-18T21:45:10.129Z","creation":"2025-02-19T02:34:20.257Z"},"accession":"S-EPMC11245956","cross_references":{"pubmed":["39007034"],"doi":["10.1016/j.jot.2024.06.003"]}}