biostudies-literatureLin WGeneral Research Fund of Shanghai Normal UniversityUniversity Grants Committee Research Grants Council63-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC11245956biostudies-literatureUnknown47<h4>Background</h4>The interaction between muscle and bone is shown to be clinically important but the underlying mechanisms are largely unknown. The canonical Wnt/β-catenin signaling pathway is reported to be involved in muscle-bone crosstalk, but its detailed function remains unclear. This systematic review aims to investigate and elucidate the role of the Wnt/β-catenin signaling pathways in muscle-bone crosstalk.<h4>Methods</h4>We conducted a literature search on the Web of Science, PubMed, EBSCO and Embase with keywords "Wnt*", "bone*" and "muscle*". A systematic review was completed according to the guideline of preferred reporting items of systematic reviews and meta-analyses (PRISMA). Data synthesis included species (human, animal or cell type used), treatments involved, outcome meaJournal of orthopaedic translationWnt/β-catenin signaling pathway as an important mediator in muscle and bone crosstalk: A systematic review.PMC1124595614114822AoE/M-402/20Chow SKHWang QWong RMYLin WZhang NLiu CChai SCui CCheung WHfalseWnt/β-catenin signaling pathway as an important mediator in muscle and bone crosstalk: A systematic review.<h4>Background</h4>The interaction between muscle and bone is shown to be clinically important but the underlying mechanisms are largely unknown. The canonical Wnt/β-catenin signaling pathway is reported to be involved in muscle-bone crosstalk, but its detailed function remains unclear. This systematic review aims to investigate and elucidate the role of the Wnt/β-catenin signaling pathways in muscle-bone crosstalk.<h4>Methods</h4>We conducted a literature search on the Web of Science, PubMed, EBSCO and Embase with keywords "Wnt*", "bone*" and "muscle*". A systematic review was completed according to the guideline of preferred reporting items of systematic reviews and meta-analyses (PRISMA). Data synthesis included species (human, animal or cell type used), treatments involved, outcome mea2024-01-01T00:00:00Z2024 Jul2025-04-18T21:45:10.129Z2025-02-19T02:34:20.257ZS-EPMC112459563900703410.1016/j.jot.2024.06.003