{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["73"],"submitter":["Chabala C"],"pubmed_abstract":["Background
In children with severe acute malnutrition (SAM) tuberculosis is common, challenging to diagnose, and often fatal. We developed tuberculosis treatment decision algorithms (TDAs) for children under the age of 5 years with SAM.Methods
In this prospective diagnostic study, we enrolled and followed up children aged <60 months hospitalised with SAM at three tertiary hospitals in Zambia and Uganda from 4 November 2019 to 20 June 2022. We included children aged 2-59 months with SAM as defined by WHO and hospitalised following the WHO clinical criteria. We excluded children with current or history of antituberculosis treatment within the preceding 3 months. They underwent tuberculosis symptom screening, clinical assessment, chest X-ray, abdominal ultrasound, Xpert MTB/RI"],"journal":["EClinicalMedicine"],"pagination":["102688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11245985"],"repository":["biostudies-literature"],"pubmed_title":["Development of tuberculosis treatment decision algorithms in children below 5 years hospitalised with severe acute malnutrition in Zambia and Uganda: a prospective diagnostic cohort study."],"pmcid":["PMC11245985"],"pubmed_authors":["Mwango E","Occelli E","Razafimanantsoa M","Beuscart A","Chimbini M","Ngambi M","Roucher C","Nangozi J","Silavwe M","Ton Nu Nguyet MH","Poublan J","Sserunjogi R","Siasulingana T","Font H","Himwaze DA","Balestre E","Nduna B","Businge GB","Kapula C","Koskas N","Serre A","Kuppers A","Barungi C","Chungu C","Zyambo K","Graham S","Inambao M","Wasswa A","Esperou H","Kapasa M","Kapotwe V","TB-Speed SAM study group","Namulinda F","Aciparu S","Wobudeya E","Charpin A","Pumbwe M","Kagoya E","Chakopo M","Lounnas M","Chirwa U","Mumba W","Kanyama M","Babirekere E","Mesnier S","Nassozi R","Marcy O","Badrichani A","Moono R","Chilanga M","Hambulo C","Mwambazi M","Bonnet M","Mankunshe E","Doreen M","Zulu S","Chilonga J","Chifunda K","Zimba K","Habiyambere G","Mulenga V","Chola D","Businge G","D'Elbee M","Vessiere A","Couffin-Cadiergues S","Ntambi S","Kasakwa K","Hellen A","Sophia C","Nawakwi G","Chabala C","Halende B","Shankalala P","Mundundu G","Hamze B"],"additional_accession":[]},"is_claimable":false,"name":"Development of tuberculosis treatment decision algorithms in children below 5 years hospitalised with severe acute malnutrition in Zambia and Uganda: a prospective diagnostic cohort study.","description":"Background
In children with severe acute malnutrition (SAM) tuberculosis is common, challenging to diagnose, and often fatal. We developed tuberculosis treatment decision algorithms (TDAs) for children under the age of 5 years with SAM.Methods
In this prospective diagnostic study, we enrolled and followed up children aged <60 months hospitalised with SAM at three tertiary hospitals in Zambia and Uganda from 4 November 2019 to 20 June 2022. We included children aged 2-59 months with SAM as defined by WHO and hospitalised following the WHO clinical criteria. We excluded children with current or history of antituberculosis treatment within the preceding 3 months. They underwent tuberculosis symptom screening, clinical assessment, chest X-ray, abdominal ultrasound, Xpert MTB/RI","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-03T00:32:24.796Z","creation":"2025-02-19T02:33:39.886Z"},"accession":"S-EPMC11245985","cross_references":{"pubmed":["39007063"],"doi":["10.1016/j.eclinm.2024.102688"]}}