{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(7)"],"submitter":["Dietz J"],"pubmed_abstract":["<h4>Background and aims</h4>Data on the prevalence and characteristics of so-called rare HCV genotypes (GTs) in larger cohorts is limited. This study investigates the frequency of rare GT and resistance-associated substitutions and the efficacy of retreatment in a European cohort.<h4>Methods</h4>A total of 129 patients with rare GT1-6 were included from the European resistance database. NS3, NS5A, and NS5B were sequenced and clinical parameters and retreatment efficacies were collected retrospectively.<h4>Results</h4>Overall 1.5% (69/4,656) of direct-acting antiviral (DAA)-naive and 4.4% (60/1,376) of DAA-failure patients were infected with rare GT. Although rare GTs were almost equally distributed throughout GT1-6 in DAA-naive patients, we detected mainly rare GT4 (47%, 28/60 GT4; of thes"],"journal":["JHEP reports : innovation in hepatology"],"pagination":["101072"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11246049"],"repository":["biostudies-literature"],"pubmed_title":["Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients."],"pmcid":["PMC11246049"],"pubmed_authors":["Dietel P","Ehrle U","Olejnik H","Durmashkina E","Friese G","Rissland J","Teubner K","Kanzler S","Schewe C","Frank M","Zizer E","Seidel T","Moradpour D","Bruch HR","John C","Berzow D","Borner N","Mroß M","Mahle I","Gschwantler M","Herrmann A","Knevels U","Boettler T","Berger F","Niehaus-Hahn S","Deterding K","Lutz U","Schulze P","Lutz T","Busch N","Steckstor W","Beretta-Piccoli BT","Emke F","Mauss S","Ebert M","Merle U","Drude L","Philipp A","Moreno C","Angeli W","Bohr U","Hurst A","Rieke A","Seufferlein T","Thimme R","Schott E","Herder M","Glaunsinger T","K","Stein K","Winzer T","Weinberger F","Magenta L","Schattenberg JM","Geyer P","Littman M","Horster H","Bucholz D","Port K","Wedemeyer H","Kerzel W","Kodal A","Muehlenberg K","Link R","Berg T","Muller-Schilling M","Koster A","Strey B","Gress M","Schleehauf D","Frick B","Canbay A","Ellenrieder V","Maurer P","European HCV Resistance Study Group","Semela D","Delker R","Gundling F","Dreher F","Riecken B","Teuber G","Kordecki N","Harter G","Diehl M","Zeuzem S","Schmiegel W","Mundlos M","Muller T","Behrends J","Rietzler S","Kluppelberg U","Nehls O","Epple HJ","Muche M","Backhus J","Mullhaupt B","Sarrazin C","Adler M","Rambach W","Giostra E","Galle P","Gunther R","Uschner F","Kuhn M","Zehnter E","Berning M","Petrides A","Gadow K","Steinmuller M","Wietzke-Braun P","Gobel U","Hametner S","Tal AO","Klugewitz K","Bruns T","Lange CM","Blaukat O","Discher T","Cornberg M","Niederau C","Teufel A","Krawczyk M","Petersen J","Klarhof M","Gustot T","Rockstroh J","Trebicka J","Mohr L","Michl P","Diedrich J","Knapp B","Heyne R","Gotze T","Stickel F","Jordan S","Rossle M","Heuchel T","Schwenzer J","Thieringer J","Naumann U","Beckebaum S","Hirschi C","Schlee P","Keitel-Anselmino V","Hartmann C","Weber A","Chave JP","Bokemeyer B","Raddant R","Felten G","Svensson K","Kallinowski B","Knecht G","Scholz D","Reiter FP","Weber T","Khaykin P","Huppe D","Burkhard O","Wolfratshausen","Bodtlander A","Hofmann WP","Trautwein C","Spengler U","Schwind HR","Baermann C","Goebel F","Hoffmann C","Hoffmann D","Graf C","Matschenz K","Geier A","Haag S","Schober A","Neumann-Haefelin C","Schulze Zur Wiesch J","Stauber R","von Felden J","Piecha F","Fischer U","Balavoine J","Heuer S","Glas M","Walter E","Willuweit K","Hampe J","Lohr H","Pinkernell M","Lohse A","Vogelmann R","Abels W","Dikopoulos N","Tacke W","Bohm G","Kapzan B","Semmo N","Fischer J","Hoffl KH","Genne D","Graf R","Seitel G","Strassburg CP","Schmidt-Heinevetter G","Wege H","Roth J","Ungemach J","Barth R","Ende K","Vermehren J","Urban G","Schneider A","Gruber H","Kunzig B","Jagel-Guedes E","Stallmach A","Lobermann M","Sternfeld T","Tomesch A","Bastlein E","Barthel K","Gorlitz B","Mainz D","Trauth J","Erhardt A","Rufle W","Werner P","Roeb E","Korfer A","Schneider M","Menges M","Schneider L","Heyer T","Reiser M","Brockmeyer NH","Rump A","Audebert F","Chirca C","Hinrichsen H","Ningel R","Jung M","Steffens H","Frederking D","Dultz G","Zachoval R","Kremer AE","Pascher E","Simon K","Dietz J","Oelmann A","Kraus M","Reinhardt L","Ullrich J","Werheid-Dobers M","Schmidt H","Seegers B","Jussios A","Garrido-Luneburg A","Schmidt W","Stenschke F","Dienethal A","Sick C","Schelling M","Beyer T","Stahler D","Moritzen D","Usadel S","Mayerle J","Langekamp A","Berg CP","Wollschlager S","Peiffer KH","Protzer U","Gute P","Schofl R","Benninger J","von Lucadou A","De Gottardi A","Piso R","Rauch A","Schulten-Baumer U","Al-Taie O","Moller H","Holst F","Tacke F","Kullig U","Glosemeyer R","Stich A","Gattringer H","Gantke B","Becker W","Seelhoff A","Maieron A","Mayer C","Klag C","Riedel M","Hilgard G","Kochsiek T","Fabris JS","Dreck M","Winter T","Sonne JU","Kocheise F","Polzien F","Pichler M","Manns M","Heinzow H","Siebler J","Schuchmann M","Baumgartl K","Buggisch P","Hunstiger M","Zipf A","Sprinzl M","Trappe U","Antoni C","Bierbaum M","Paulweber B"],"additional_accession":[]},"is_claimable":false,"name":"Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients.","description":"<h4>Background and aims</h4>Data on the prevalence and characteristics of so-called rare HCV genotypes (GTs) in larger cohorts is limited. This study investigates the frequency of rare GT and resistance-associated substitutions and the efficacy of retreatment in a European cohort.<h4>Methods</h4>A total of 129 patients with rare GT1-6 were included from the European resistance database. NS3, NS5A, and NS5B were sequenced and clinical parameters and retreatment efficacies were collected retrospectively.<h4>Results</h4>Overall 1.5% (69/4,656) of direct-acting antiviral (DAA)-naive and 4.4% (60/1,376) of DAA-failure patients were infected with rare GT. Although rare GTs were almost equally distributed throughout GT1-6 in DAA-naive patients, we detected mainly rare GT4 (47%, 28/60 GT4; of thes","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-18T21:45:01.821Z","creation":"2025-02-19T02:34:26.601Z"},"accession":"S-EPMC11246049","cross_references":{"pubmed":["39006503"],"doi":["10.1016/j.jhepr.2024.101072"]}}