{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Zhu J"],"pubmed_abstract":["Analogous of pixels to two-dimensional pictures, voxels-in the form of either small cubes or spheres-are the basic building blocks of three-dimensional objects. However, precise manipulation of viscoelastic bio-ink voxels in three-dimensional space represents a grand challenge in both soft matter science and biomanufacturing. Here, we present a voxelated bioprinting technology that enables the digital assembly of interpenetrating double-network hydrogel droplets made of polyacrylamide/alginate-based or hyaluronic acid/alginate-based polymers. The hydrogels are crosslinked via additive-free and biofriendly click reaction between a pair of stoichiometrically matched polymers carrying norbornene and tetrazine groups, respectively. We develop theoretical frameworks to describe the crosslinking"],"journal":["Nature communications"],"pagination":["5902"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11246467"],"repository":["biostudies-literature"],"pubmed_title":["Voxelated bioprinting of modular double-network bio-ink droplets."],"pmcid":["PMC11246467"],"pubmed_authors":["Zhu J","He Y","Cai LH","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Voxelated bioprinting of modular double-network bio-ink droplets.","description":"Analogous of pixels to two-dimensional pictures, voxels-in the form of either small cubes or spheres-are the basic building blocks of three-dimensional objects. However, precise manipulation of viscoelastic bio-ink voxels in three-dimensional space represents a grand challenge in both soft matter science and biomanufacturing. Here, we present a voxelated bioprinting technology that enables the digital assembly of interpenetrating double-network hydrogel droplets made of polyacrylamide/alginate-based or hyaluronic acid/alginate-based polymers. The hydrogels are crosslinked via additive-free and biofriendly click reaction between a pair of stoichiometrically matched polymers carrying norbornene and tetrazine groups, respectively. We develop theoretical frameworks to describe the crosslinking","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-06-01T00:12:24.876Z","creation":"2024-11-12T23:24:35.82Z"},"accession":"S-EPMC11246467","cross_references":{"pubmed":["39003266"],"doi":["10.1038/s41467-024-49705-z"]}}