biostudies-literatureAntman-Passig MNational Institute of Neurological Disorders and StrokeAra Parseghian Medical Research FundLouis and Rachel Rudin FoundationMemorial Sloan-Kettering Cancer CenterExpect Miracles FoundationJoe W. and Dorothy Dorsett Brown FoundationBreak Through CancerCycle for SurvivalCommonwealth Foundation for Cancer Research FoundationNational Cancer InstituteNINDS NIH HHSNCI NIH HHSEmerson CollectiveDivision of Chemical, Bioengineering, Environmental, and Transport SystemsOvarian Cancer Research Alliance10687-10695https://www.ebi.ac.uk/biostudies/studies/S-EPMC11246544biostudies-literatureUnknown23(23)Dysregulated lipid metabolism contributes to neurodegenerative pathologies and neurological decline in lysosomal storage disorders as well as more common neurodegenerative diseases. Niemann-Pick type A (NPA) is a fatal neurodegenerative lysosomal storage disease characterized by abnormal sphingomyelin accumulation in the endolysosomal lumen. The ability to monitor abnormalities in lipid homeostasis intracranially could improve basic investigations and the development of effective treatment strategies. We investigated the carbon nanotube-based detection of intracranial lipid content. We found that the near-infrared emission of a carbon nanotube-based lipid sensor responds to lipid accumulation in neuronal and in vivo models of NPA. The nanosensor detected lipid accumulation intracranially iNano lettersNanoreporter Identifies Lysosomal Storage Disease Lipid Accumulation Intracranially.PMC11246544R01 NS122987R01 NS116353R01-NS116353R01-NS122987P30 CA0087481752506U54CA132378P30-CA008748U54 CA132378Haimovitz-Friedman AGoerzen DAntman-Passig MYaari ZHeller DAMathieu MChatman SParikh RKomer LEChen CGrabarnik EfalseNanoreporter Identifies Lysosomal Storage Disease Lipid Accumulation Intracranially.Dysregulated lipid metabolism contributes to neurodegenerative pathologies and neurological decline in lysosomal storage disorders as well as more common neurodegenerative diseases. Niemann-Pick type A (NPA) is a fatal neurodegenerative lysosomal storage disease characterized by abnormal sphingomyelin accumulation in the endolysosomal lumen. The ability to monitor abnormalities in lipid homeostasis intracranially could improve basic investigations and the development of effective treatment strategies. We investigated the carbon nanotube-based detection of intracranial lipid content. We found that the near-infrared emission of a carbon nanotube-based lipid sensor responds to lipid accumulation in neuronal and in vivo models of NPA. The nanosensor detected lipid accumulation intracranially i2023-01-01T00:00:00Z2023 Dec2025-04-04T01:20:24.814Z2025-04-04T01:20:24.814ZS-EPMC112465443788987410.1021/acs.nanolett.3c02502