{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cooper PO"],"funding":["George Washington University","National Institute of Arthritis and Musculoskeletal and Skin Diseases","Galápagos","NIDDK NIH HHS","NCI NIH HHS","NIAMS NIH HHS","NIH","University of Arizona Cancer Center"],"pagination":["114288"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247419"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(6)"],"pubmed_abstract":["Lipids have emerged as potent regulators of immune cell function. In the skin, adipocyte lipolysis increases the local pool of free fatty acids and is essential for coordinating early macrophage inflammation following injury. Here, we investigate G-protein-coupled receptor 84 (GPR84), a medium-chain fatty acid (MCFA) receptor, for its potential to propagate pro-inflammatory signaling after skin injury. GPR84 signaling was identified as a key component of regulating myeloid cell numbers and subsequent tissue repair through in vivo administration of a pharmacological antagonist and the MCFA decanoic acid. We found that impaired injury-induced dermal adipocyte lipolysis is a hallmark of diabetes, and lipidomic analysis demonstrated that MCFAs are significantly reduced in diabetic murine wound"],"journal":["Cell reports"],"pubmed_title":["G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds."],"pmcid":["PMC11247419"],"funding_grant_id":["DK109079","AR082417","T32 CA247756","GLPG1205","R03 DK122189","DK122189-01","K01 DK109079","R01 AR082417"],"pubmed_authors":["Gupta R","Cooper PO","Nguyen DV","Dhaliwal TK","Shook BA","Nguyen BN","Amuso VM","Babirye NS","Mazumder MF","Kleb SS","Varshney R","Rudolph MC","Noonepalle SK"],"additional_accession":[]},"is_claimable":false,"name":"G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds.","description":"Lipids have emerged as potent regulators of immune cell function. In the skin, adipocyte lipolysis increases the local pool of free fatty acids and is essential for coordinating early macrophage inflammation following injury. Here, we investigate G-protein-coupled receptor 84 (GPR84), a medium-chain fatty acid (MCFA) receptor, for its potential to propagate pro-inflammatory signaling after skin injury. GPR84 signaling was identified as a key component of regulating myeloid cell numbers and subsequent tissue repair through in vivo administration of a pharmacological antagonist and the MCFA decanoic acid. We found that impaired injury-induced dermal adipocyte lipolysis is a hallmark of diabetes, and lipidomic analysis demonstrated that MCFAs are significantly reduced in diabetic murine wound","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-25T19:15:17.339Z","creation":"2025-04-06T07:55:08.418Z"},"accession":"S-EPMC11247419","cross_references":{"pubmed":["38814782"],"doi":["10.1016/j.celrep.2024.114288"]}}