{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang H"],"funding":["the Haiyan Foundation of Harbin Medical University Cancer Hospital","the Beijing Medical Award Foundation"],"pagination":["2444-2460"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247557"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(7)"],"pubmed_abstract":["Peripheral T-cell lymphoma (PTCL) is a highly aggressive type of non-Hodgkin's lymphoma with a poor prognosis. Pyroptosis is a newly discovered procedural cell death mode, which has been implicated to occur in both tumor cells and immune cells. However, the occurrence and effect of pyroptosis on PTCL remain unclear. Here, we found that pyroptosis occurred in interstitial macrophages of PTCL rather than in tumor cells. In clinical specimens, macrophage pyroptosis was associated with a poor prognosis of PTCL. In vitro experiments and gene sequencing results showed that pyroptotic macrophages could upregulate the expression of TLR4 through secreting inflammatory cytokines IL-18. Upregulated TLR4 activated its downstream NF-κB anti-apoptotic signaling pathway, thus leading to malignant prolife"],"journal":["Cancer science"],"pubmed_title":["Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T-cell lymphoma via TLR4 signaling pathway."],"pmcid":["PMC11247557"],"funding_grant_id":["YXJL-2020-0785-1072","JJQN 2023-01","JJZD 2022-10"],"pubmed_authors":["Yang H","Li H","Zhao S","Zhang Z","Zhang Y","Zhang H","Yang M","Zhao W","Li L","Gao S","Ma W"],"additional_accession":[]},"is_claimable":false,"name":"Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T-cell lymphoma via TLR4 signaling pathway.","description":"Peripheral T-cell lymphoma (PTCL) is a highly aggressive type of non-Hodgkin's lymphoma with a poor prognosis. Pyroptosis is a newly discovered procedural cell death mode, which has been implicated to occur in both tumor cells and immune cells. However, the occurrence and effect of pyroptosis on PTCL remain unclear. Here, we found that pyroptosis occurred in interstitial macrophages of PTCL rather than in tumor cells. In clinical specimens, macrophage pyroptosis was associated with a poor prognosis of PTCL. In vitro experiments and gene sequencing results showed that pyroptotic macrophages could upregulate the expression of TLR4 through secreting inflammatory cytokines IL-18. Upregulated TLR4 activated its downstream NF-κB anti-apoptotic signaling pathway, thus leading to malignant prolife","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-25T19:17:14.715Z","creation":"2025-04-06T07:54:00.63Z"},"accession":"S-EPMC11247557","cross_references":{"pubmed":["38613253"],"doi":["10.1111/cas.16180"]}}