{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(6)"],"submitter":["Li X"],"pubmed_abstract":["<h4>Background</h4>There have been studies on the role of sperm-associated antigen 6 <i>(SPAG6</i>) in cytoskeleton formation and growth cone stability, but it is also unknown how spag6 affect tumor growth and development. The aim of this study was to clarify the role of <i>SPAG6</i> in pan-cancer, with some findings about thyroid carcinoma (THCA) validated through experiments.<h4>Methods</h4>We examined the role of <i>SPAG6</i> in pan-cancer, with the data being collected from databases. Further analysis was conducted to assess its correlations with prognosis, gene heterogeneity, stemness, and tumor immunity. The interacting proteins of <i>SPAG6</i> were also identified, and gene ontology enrichment analysis was performed to determine its biological function. We preliminarily confirmed th"],"journal":["Gland surgery"],"pagination":["999-1015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247597"],"repository":["biostudies-literature"],"pubmed_title":["A comprehensive pan-cancer analysis revealing <i>SPAG6</i> as a novel diagnostic, prognostic and immunological biomarker in tumor."],"pmcid":["PMC11247597"],"pubmed_authors":["Li X","Kong L","Zhang D","Wang H","Wang Y","Diez JJ"],"additional_accession":[]},"is_claimable":false,"name":"A comprehensive pan-cancer analysis revealing <i>SPAG6</i> as a novel diagnostic, prognostic and immunological biomarker in tumor.","description":"<h4>Background</h4>There have been studies on the role of sperm-associated antigen 6 <i>(SPAG6</i>) in cytoskeleton formation and growth cone stability, but it is also unknown how spag6 affect tumor growth and development. The aim of this study was to clarify the role of <i>SPAG6</i> in pan-cancer, with some findings about thyroid carcinoma (THCA) validated through experiments.<h4>Methods</h4>We examined the role of <i>SPAG6</i> in pan-cancer, with the data being collected from databases. Further analysis was conducted to assess its correlations with prognosis, gene heterogeneity, stemness, and tumor immunity. The interacting proteins of <i>SPAG6</i> were also identified, and gene ontology enrichment analysis was performed to determine its biological function. We preliminarily confirmed th","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-26T05:35:30.741Z","creation":"2025-04-06T11:30:24.956Z"},"accession":"S-EPMC11247597","cross_references":{"pubmed":["39015705"],"doi":["10.21037/gs-24-157"]}}