{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ying Y"],"funding":["US National Institutes of Health","Science and Technology Commission of Shanghai Municipality","Shanghai Municipal Health Commission","National Natural Science Foundation of China","NINDS NIH HHS"],"pagination":["4527-4539"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247670"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(7)"],"pubmed_abstract":["<h4>Introduction</h4>We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K<sup>trans</sup>) and BBB water exchange rate (k<sub>w</sub>) varied in cerebral small vessel disease (cSVD) subtypes.<h4>Methods</h4>Thirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high-temperature requirement factor A serine peptidase 1 (HTRA) -related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.<h4>Results</h4>In CADASIL, no difference in K<sup>trans</sup>, but lower k<sub>w</sub> was observed in multiple brain regions. In sporadic cSVD, no difference in k<sub>w</sub>, but higher K<sup>trans</sup> was found in the whole b"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases."],"pmcid":["PMC11247670"],"funding_grant_id":["2022XD022","92249301","20Z11900802","82025018","R01 NS114382","82271352","R01NS114382","81961128030","81971123"],"pubmed_authors":["Chabriat H","Li Y","Shao X","Wang DJJ","Wang C","Ying Y","Yao T","Montagne A","Yang Q","Tang W","Cheng X"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases.","description":"<h4>Introduction</h4>We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K<sup>trans</sup>) and BBB water exchange rate (k<sub>w</sub>) varied in cerebral small vessel disease (cSVD) subtypes.<h4>Methods</h4>Thirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high-temperature requirement factor A serine peptidase 1 (HTRA) -related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.<h4>Results</h4>In CADASIL, no difference in K<sup>trans</sup>, but lower k<sub>w</sub> was observed in multiple brain regions. In sporadic cSVD, no difference in k<sub>w</sub>, but higher K<sup>trans</sup> was found in the whole b","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-25T19:12:19.618Z","creation":"2025-04-06T07:54:36.617Z"},"accession":"S-EPMC11247670","cross_references":{"pubmed":["38787758"],"doi":["10.1002/alz.13874"]}}