biostudies-literatureYing YUS National Institutes of HealthScience and Technology Commission of Shanghai MunicipalityShanghai Municipal Health CommissionNational Natural Science Foundation of ChinaNINDS NIH HHS4527-4539https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247670biostudies-literatureUnknown20(7)<h4>Introduction</h4>We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K^trans) and BBB water exchange rate (k_w) varied in cerebral small vessel disease (cSVD) subtypes.<h4>Methods</h4>Thirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high-temperature requirement factor A serine peptidase 1 (HTRA) -related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.<h4>Results</h4>In CADASIL, no difference in K^trans, but lower k_w was observed in multiple brain regions. In sporadic cSVD, no difference in k_w, but higher K^trans was found in the whole bAlzheimer's & dementia : the journal of the Alzheimer's AssociationHeterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases.PMC112476702022XD0229224930120Z1190080282025018R01 NS11438282271352R01NS1143828196112803081971123Chabriat HLi YShao XWang DJJWang CYing YYao TMontagne AYang QTang WCheng XfalseHeterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases.<h4>Introduction</h4>We explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K^trans) and BBB water exchange rate (k_w) varied in cerebral small vessel disease (cSVD) subtypes.<h4>Methods</h4>Thirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high-temperature requirement factor A serine peptidase 1 (HTRA) -related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.<h4>Results</h4>In CADASIL, no difference in K^trans, but lower k_w was observed in multiple brain regions. In sporadic cSVD, no difference in k_w, but higher K^trans was found in the whole b2024-01-01T00:00:00Z2024 Jul2025-04-25T19:12:19.618Z2025-04-06T07:54:36.617ZS-EPMC112476703878775810.1002/alz.13874