biostudies-literatureLiu YNational Key R&D Program of ChinaSTI2030-Major ProjectsNational Clinical Research Center for Geriatric DisordersXiangya HospitalChina Postdoctoral Science FoundationNational Natural Science Foundation of ChinaScience and Technology Major Project of Hunan ProvinceNational Key Research and Development Program of ChinaScience and Technology Innovation Program of Hunan ProvinceXiangya Hospital, Central South University4841-4853https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247675biostudies-literatureUnknown20(7)<h4>Introduction</h4>The cognitive impairment patterns and the association with Alzheimer's disease (AD) in mental disorders remain poorly understood.<h4>Methods</h4>We analyzed data from 486,297 UK Biobank participants, categorizing them by mental disorder history to identify the risk of AD and the cognitive impairment characteristics. Causation was further assessed using Mendelian randomization (MR).<h4>Results</h4>AD risk was higher in individuals with bipolar disorder (BD; hazard ratio [HR] = 2.37, P < 0.01) and major depressive disorder (MDD; HR = 1.63, P < 0.001). MR confirmed a causal link between BD and AD (OR_IVW= 1.098), as well as obsessive-compulsive disorder (OCD) and AD (OR_IVW= 1.050). Cognitive impairments varied, with BD and schizophrenia showing wideAlzheimer's & dementia : the journal of the Alzheimer's AssociationThe risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis.PMC112476752022M7235542021SK102082001358U22A203002021JJ410462021ZD02018032022LNJJ162023YFC3603700823714342021RC3028Yang XLiu YShen LYang YJiao BZhu YXiao XYao RYang QZhang SfalseThe risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis.<h4>Introduction</h4>The cognitive impairment patterns and the association with Alzheimer's disease (AD) in mental disorders remain poorly understood.<h4>Methods</h4>We analyzed data from 486,297 UK Biobank participants, categorizing them by mental disorder history to identify the risk of AD and the cognitive impairment characteristics. Causation was further assessed using Mendelian randomization (MR).<h4>Results</h4>AD risk was higher in individuals with bipolar disorder (BD; hazard ratio [HR] = 2.37, P < 0.01) and major depressive disorder (MDD; HR = 1.63, P < 0.001). MR confirmed a causal link between BD and AD (OR_IVW= 1.098), as well as obsessive-compulsive disorder (OCD) and AD (OR_IVW= 1.050). Cognitive impairments varied, with BD and schizophrenia showing wide2024-01-01T00:00:00Z2024 Jul2025-04-26T14:16:03.096Z2025-04-06T14:30:46.88ZS-EPMC112476753886075110.1002/alz.14049