{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dunham SJB"],"funding":["NIA NIH HHS","Hewitt Foundation for Biomedical Research","NCI NIH HHS","National Cancer Institute of the National Institutes of Health","National Institute on Aging"],"pagination":["4935-4950"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(7)"],"pubmed_abstract":["<h4>Introduction</h4>Emerging evidence links changes in the gut microbiome to late-onset Alzheimer's disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome.<h4>Methods</h4>We used shotgun metagenomics and untargeted metabolomics to study the human amyloid beta knock-in (hAβ-KI) murine model for LOAD compared to both wild-type (WT) mice and a model for early-onset AD (3xTg-AD).<h4>Results</h4>Eighteen-month female (but not male) hAβ-KI microbiomes were distinct from WT microbiomes, with AD genotype accounting for 18% of the variance by permutational multivariate analysis of variance (PERMANOVA). Metabolomic diversity differences were observed in females, however no individual metabolites were differentially abundant. hAβ-KI mice microbiomes were di"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice."],"pmcid":["PMC11247698"],"funding_grant_id":["T32 AG00096‐38","P30 CA062203","T32 AG000096","T32 AG00096-38","U54 AG054349","P30CA062203"],"pubmed_authors":["Avelar-Barragan J","Mapstone M","Rothman JA","Kawauchi S","Forner S","Dunham SJB","Faraci G","MacGregor GR","Adams ED","Whiteson KL","Green KN","Tenner AJ","LaFerla FM"],"additional_accession":[]},"is_claimable":false,"name":"Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice.","description":"<h4>Introduction</h4>Emerging evidence links changes in the gut microbiome to late-onset Alzheimer's disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome.<h4>Methods</h4>We used shotgun metagenomics and untargeted metabolomics to study the human amyloid beta knock-in (hAβ-KI) murine model for LOAD compared to both wild-type (WT) mice and a model for early-onset AD (3xTg-AD).<h4>Results</h4>Eighteen-month female (but not male) hAβ-KI microbiomes were distinct from WT microbiomes, with AD genotype accounting for 18% of the variance by permutational multivariate analysis of variance (PERMANOVA). Metabolomic diversity differences were observed in females, however no individual metabolites were differentially abundant. hAβ-KI mice microbiomes were di","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-02T22:24:07.581Z","creation":"2024-12-04T03:17:08.105Z"},"accession":"S-EPMC11247698","cross_references":{"pubmed":["38572865"],"doi":["10.1002/alz.13794"]}}