biostudies-literatureBodinier MAssociation Nationale de la Recherche et de la Technologie240https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247757biostudies-literatureUnknown28(1)<h4>Background</h4>The immune response of critically ill patients, such as those with sepsis, severe trauma, or major surgery, is heterogeneous and dynamic, but its characterization and impact on outcomes are poorly understood. Until now, the primary challenge in advancing our understanding of the disease has been to concurrently address both multiparametric and temporal aspects.<h4>Methods</h4>We used a clustering method to identify distinct groups of patients, based on various immune marker trajectories during the first week after admission to ICU. In 339 severely injured patients, we initially longitudinally clustered common biomarkers (both soluble and cellular parameters), whose variations are well-established during the immunosuppressive phase of sepsis. We then applied this multi-trCritical care (London, England)Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients.PMC112477572020/0371Carre CBequet FGardiner DCaruso LRaychaudhuri AMartin OTissot SOriol GTruc CKoenig NTextoris JCrozon-Clauzel JBounab YHuriaux LJourdan CMallet FDebord-Peguet SGregoire AREALISM study groupMommert MGatel JUberti TRiffaud CBerger SBDevigne BVallin HMaucort-Boulch DGenin CFlorin KBrengel-Pesce KMoriceau FGallet-Gorius EMeuret PMacnamara AMoriniere JPeleraux AHengy BGillespie IToetsch SAugris-Mathieu CCollus MArnal SDelsuc CLouis KTabone OCanard BRimmele Tde Monfort ABenatir FTran TBen-Amor ACerro VLepape ASchrevel CMouscaz YMoucadel VBrajon FSmylie RPerret MDelwarde BJadaud CMonneret GMonard CGough PJPayrard SPachot ARol MLReynier FMeunier BMistretta MAshton TPeronnet ETan LBertin-Maghit MFugier IPanel NGorse IGarcon NLeissner PSapay NBodinier MCejka JCRahali NFaure ACortez PFraisse LMarcotte GBlein SBertin-Maghit ABouffard YDavidson JLeray VVedrine CKreitmann LBecker JLukaszewicz ACMatray MCheynet VGirardot TFayolle-Pivot LBer CEDeleat-Besson RLlitjos JFGuyard CNoailles LLavocat FBayle FCerrato EQuemeneur LBellocq ASMarcos JYBoibieux AZadam AFleurie AGriffiths AFloccard BGuichard AVenet FTipple CfalseIntegrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients.<h4>Background</h4>The immune response of critically ill patients, such as those with sepsis, severe trauma, or major surgery, is heterogeneous and dynamic, but its characterization and impact on outcomes are poorly understood. Until now, the primary challenge in advancing our understanding of the disease has been to concurrently address both multiparametric and temporal aspects.<h4>Methods</h4>We used a clustering method to identify distinct groups of patients, based on various immune marker trajectories during the first week after admission to ICU. In 339 severely injured patients, we initially longitudinally clustered common biomarkers (both soluble and cellular parameters), whose variations are well-established during the immunosuppressive phase of sepsis. We then applied this multi-tr2024-01-01T00:00:00Z2024 Jul2026-06-02T23:28:09.194Z2025-04-06T11:34:08.629ZS-EPMC112477573901011310.1186/s13054-024-04990-4