{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu Q"],"funding":["Guangzhou Science and Technology Plan Project","the Guangzhou Science and Technology Plan Project","Guangzhou Municipal Institute Enterprise Joint Funding Project","Science and Technology Project of Foshan","Natural Science Foundation of Guangdong Province"],"pagination":["50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11247778"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Background
Estrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recurrences still threaten patients' long-term survival and quality of life. Finding candidate tumor antigens and potential therapeutic targets is critical to addressing these unmet needs.Method
The isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis was employed to identify the differentially expressed proteins (DEPs) between ER + breast cancer and corresponding adjacent normal tissue. Candidate DEPs were screened by bioinformatic analyses, and their expression was confirmed by immunohistochemical (IHC) staining and western blot. A series of in vitro experiments, including wound healing assay, colony formation, and cell"],"journal":["Clinical proteomics"],"pubmed_title":["ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis."],"pmcid":["PMC11247778"],"funding_grant_id":["202103000051","202102010101","2220001004797","SL2024A03J00312","2024A04J9904","2019A1515110044"],"pubmed_authors":["Qu C","Yang Z","Chen P","Li Z","Zhang K","Zhang Y","Yu Q","Liang J","Liu S","Yang A","Sun H"],"additional_accession":[]},"is_claimable":false,"name":"ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis.","description":"Background
Estrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recurrences still threaten patients' long-term survival and quality of life. Finding candidate tumor antigens and potential therapeutic targets is critical to addressing these unmet needs.Method
The isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis was employed to identify the differentially expressed proteins (DEPs) between ER + breast cancer and corresponding adjacent normal tissue. Candidate DEPs were screened by bioinformatic analyses, and their expression was confirmed by immunohistochemical (IHC) staining and western blot. A series of in vitro experiments, including wound healing assay, colony formation, and cell","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-25T19:12:54.27Z","creation":"2025-04-06T07:53:50.384Z"},"accession":"S-EPMC11247778","cross_references":{"pubmed":["39004717"],"doi":["10.1186/s12014-024-09502-8"]}}