biostudies-literatureRiggs CLNational Institutes of General Medical Sciencese202307146https://www.ebi.ac.uk/biostudies/studies/S-EPMC11248227biostudies-literatureUnknown223(10)Stress triggers the formation of two distinct cytoplasmic biomolecular condensates: stress granules (SGs) and processing bodies (PBs), both of which may contribute to stress-responsive translation regulation. Though PBs can be present constitutively, stress can increase their number and size and lead to their interaction with stress-induced SGs. The mechanism of such interaction, however, is largely unknown. Formation of canonical SGs requires the RNA binding protein Ubiquitin-Associated Protein 2-Like (UBAP2L), which is a central SG node protein in the RNA-protein interaction network of SGs and PBs. UBAP2L binds to the essential SG and PB proteins G3BP and DDX6, respectively. Research on UBAP2L has mostly focused on its role in SGs, but not its connection to PBs. We find that UBAP2L is noThe Journal of cell biologyUBAP2L contributes to formation of P-bodies and modulates their association with stress granules.PMC11248227R01 GM126150F32GM142262K99GM148723R01 GM146997R35GM12901Zubair SNAnderson PAmarsanaa MIvanov PRiggs CLKedersha NfalseUBAP2L contributes to formation of P-bodies and modulates their association with stress granules.Stress triggers the formation of two distinct cytoplasmic biomolecular condensates: stress granules (SGs) and processing bodies (PBs), both of which may contribute to stress-responsive translation regulation. Though PBs can be present constitutively, stress can increase their number and size and lead to their interaction with stress-induced SGs. The mechanism of such interaction, however, is largely unknown. Formation of canonical SGs requires the RNA binding protein Ubiquitin-Associated Protein 2-Like (UBAP2L), which is a central SG node protein in the RNA-protein interaction network of SGs and PBs. UBAP2L binds to the essential SG and PB proteins G3BP and DDX6, respectively. Research on UBAP2L has mostly focused on its role in SGs, but not its connection to PBs. We find that UBAP2L is no2024-01-01T00:00:00Z2024 Oct2025-04-25T19:20:12.818Z2025-04-06T07:54:45.355ZS-EPMC112482273900780310.1083/jcb.202307146