biostudies-literatureUnknown4(7)Omonkhua AAThe World Bank - Regional Disease Surveillance Systems Enhancement (REDISSEThe COVID-19 pandemic challenged health systems globally. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for detecting the presence of SARS-CoV-2 in clinical samples. Rapid diagnostic test (RDT) kits for COVID-19 have been widely used in Nigeria. This has greatly improved test turnover rates and significantly decreased the high technical demands of RT-PCR. However, there is currently no nationally representative evaluation of the performance characteristics and reliability of these kits. This study assessed the sensitivity, specificity, and predictive values of ten RDT kits used for COVID-19 testing in Nigeria. This large multi-centred cross-sectional study was conducted across the 6 geo-political zones of Nigeria over four months. Ten antigen (Ag) and antiboPLOS global public healthe0003371https://www.ebi.ac.uk/biostudies/studies/S-EPMC11249252biostudies-literaturePerformance evaluation of SARS-CoV-2 rapid diagnostic tests in Nigeria: A cross-sectional study.PMC11249252Odeh EOnyeaghala AOchu CLOjo TSimon OOpayele AVAdetifa IKida IJibrin YBMahmoud MAOhonsi CBimba JSTolulupe AOnayade ACOVID-19 RDT Validation in Nigeria (CORVAN) study groupBogoro SFaneye AIhekweazu CAbubakar AOkonofua FEdem VFEl-Fulatty AROlusola TMaigari IMPopoola MPam D LOdaibo GNEvaezi OAmeh EOsaigbovo IIEmmanuel NDavid SNtoimo LIgbarumah ISimji GFolarin OElimian KEliya TObaseki DEOlaleye DOOmonkhua AAAkinduti PMaduka OOlugbile MHappi CAkinwande KSAlhaji SAbi IJIgumbor ESalako BShehu NYfalsePerformance evaluation of SARS-CoV-2 rapid diagnostic tests in Nigeria: A cross-sectional study.The COVID-19 pandemic challenged health systems globally. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for detecting the presence of SARS-CoV-2 in clinical samples. Rapid diagnostic test (RDT) kits for COVID-19 have been widely used in Nigeria. This has greatly improved test turnover rates and significantly decreased the high technical demands of RT-PCR. However, there is currently no nationally representative evaluation of the performance characteristics and reliability of these kits. This study assessed the sensitivity, specificity, and predictive values of ten RDT kits used for COVID-19 testing in Nigeria. This large multi-centred cross-sectional study was conducted across the 6 geo-political zones of Nigeria over four months. Ten antigen (Ag) and antibo2024-01-01T00:00:00Z20242025-04-25T19:18:29.704Z2025-04-06T07:54:11.618ZS-EPMC112492523900848510.1371/journal.pgph.0003371