{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Memon D"],"funding":["Cancer Research UK","NCI NIH HHS"],"pagination":["209-224.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11249385"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(2)"],"pubmed_abstract":["Although immunotherapy with PD-(L)1 blockade is routine for lung cancer, little is known about acquired resistance. Among 1,201 patients with non-small cell lung cancer (NSCLC) treated with PD-(L)1 blockade, acquired resistance is common, occurring in >60% of initial responders. Acquired resistance shows differential expression of inflammation and interferon (IFN) signaling. Relapsed tumors can be separated by upregulated or stable expression of IFNγ response genes. Upregulation of IFNγ response genes is associated with putative routes of resistance characterized by signatures of persistent IFN signaling, immune dysfunction, and mutations in antigen presentation genes which can be recapitulated in multiple murine models of acquired resistance to PD-(L)1 blockade after in vitro IFNγ treatme"],"journal":["Cancer cell"],"pubmed_title":["Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer."],"pmcid":["PMC11249385"],"funding_grant_id":["P30 CA008748","21141"],"pubmed_authors":["Qiu J","Rizvi H","Fromm G","Beltrao P","Yoo KJ","Greenbaum BD","Plodkowski AJ","Chow A","Achour I","Hellmann MD","Luksza M","McGranahan N","Miller ML","Sauter JL","Bhanot UK","Schreiber TH","Minn AJ","Abu-Akeel M","Lihm J","Vanderbilt CM","Stewart R","Barrett JC","Mathew D","Memon D","Luo J","Schoenfeld AJ","Zhang X","Keddar MR","Ye D","Miriyala J","Liu C","Merghoub T","McCarthy C"],"additional_accession":[]},"is_claimable":false,"name":"Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer.","description":"Although immunotherapy with PD-(L)1 blockade is routine for lung cancer, little is known about acquired resistance. Among 1,201 patients with non-small cell lung cancer (NSCLC) treated with PD-(L)1 blockade, acquired resistance is common, occurring in >60% of initial responders. Acquired resistance shows differential expression of inflammation and interferon (IFN) signaling. Relapsed tumors can be separated by upregulated or stable expression of IFNγ response genes. Upregulation of IFNγ response genes is associated with putative routes of resistance characterized by signatures of persistent IFN signaling, immune dysfunction, and mutations in antigen presentation genes which can be recapitulated in multiple murine models of acquired resistance to PD-(L)1 blockade after in vitro IFNγ treatme","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-01T13:00:38.181Z","creation":"2025-04-04T13:11:16.69Z"},"accession":"S-EPMC11249385","cross_references":{"pubmed":["38215748"],"doi":["10.1016/j.ccell.2023.12.013"]}}