{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu CY"],"funding":["National Institute of Environmental Health Sciences","National Center for Advancing Translational Sciences","Eunice Kennedy Shriver National Institute of Child Health and Human Development","NCATS NIH HHS","NICHD NIH HHS","NIEHS NIH HHS","Icahn School of Medicine at Mount Sinai","National Institute of Child Health and Human Development"],"pagination":["134863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11250751"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["475"],"pubmed_abstract":["Early life phthalates exposure has been associated with adverse respiratory outcomes. However, evidence linking prenatal phthalates exposure and childhood lung function has been inconclusive. Additionally, few studies have examined phthalates exposure as a mixture and explored sexually dimorphic associations. We aimed to investigate sex-specific associations of prenatal phthalates mixtures with childhood lung function using the PROGRESS cohort in Mexico (N = 476). Prenatal phthalate concentrations were measured in maternal urine collected during the 2<sup>nd</sup> and 3<sup>rd</sup> trimesters. Children's lung function was evaluated at ages 8-13 years. Individual associations were assessed using multivariable linear regression, and mixture associations were modeled using repeated holdout WQS regression and hierarchical BKMR; data was stratified by sex to explore sex-specific associations. We identified significant interactions between 2<sup>nd</sup> trimester phthalates mixture and sex on FEV<sub>1</sub> and FVC z-scores. Higher 2<sup>nd</sup> trimester phthalate concentrations were associated with higher FEV<sub>1</sub> (β = 0.054, 95 %CI: 0.005, 0.104) and FVC z-scores (β = 0.074, 95 % CI: 0.024, 0.124) in females and with lower measures in males (FEV<sub>1</sub>, β = -0.017, 95 %CI: -0.066, 0.026; FVC, β = -0.014, 95 %CI: -0.065, 0.030). This study indicates that prenatal exposure to phthalates is related to childhood lung function in a sex-specific manner."],"journal":["Journal of hazardous materials"],"pubmed_title":["Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children."],"pmcid":["PMC11250751"],"funding_grant_id":["R01ES033245","K99 ES035894","P30ES023515","R00ES027496","UL1 TR004419","T32HD049311","R00 ES027496","R01ES014930","R01 ES013744","R01ES013744","R01 ES014930","R01ES021357","P30 ES023515","R01 ES033245","R24ES028522","R01 ES021357","T32 HD049311","R24 ES028522","UL1TR004419","L40 ES034609"],"pubmed_authors":["Hu CY","Gennings C","Just AC","Rivera Rivera N","Tamayo-Ortiz M","Mercado-Garcia A","Carroll KN","Wright RJ","Tellez-Rojo MM","Rosa MJ","Lamadrid-Figueroa H","Alcala CS","Wright RO"],"additional_accession":[]},"is_claimable":false,"name":"Associations of prenatal exposure to phthalates and their mixture with lung function in Mexican children.","description":"Early life phthalates exposure has been associated with adverse respiratory outcomes. However, evidence linking prenatal phthalates exposure and childhood lung function has been inconclusive. Additionally, few studies have examined phthalates exposure as a mixture and explored sexually dimorphic associations. We aimed to investigate sex-specific associations of prenatal phthalates mixtures with childhood lung function using the PROGRESS cohort in Mexico (N = 476). Prenatal phthalate concentrations were measured in maternal urine collected during the 2<sup>nd</sup> and 3<sup>rd</sup> trimesters. Children's lung function was evaluated at ages 8-13 years. Individual associations were assessed using multivariable linear regression, and mixture associations were modeled using repeated holdout WQS regression and hierarchical BKMR; data was stratified by sex to explore sex-specific associations. We identified significant interactions between 2<sup>nd</sup> trimester phthalates mixture and sex on FEV<sub>1</sub> and FVC z-scores. Higher 2<sup>nd</sup> trimester phthalate concentrations were associated with higher FEV<sub>1</sub> (β = 0.054, 95 %CI: 0.005, 0.104) and FVC z-scores (β = 0.074, 95 % CI: 0.024, 0.124) in females and with lower measures in males (FEV<sub>1</sub>, β = -0.017, 95 %CI: -0.066, 0.026; FVC, β = -0.014, 95 %CI: -0.065, 0.030). This study indicates that prenatal exposure to phthalates is related to childhood lung function in a sex-specific manner.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-05-01T03:29:44.939Z","creation":"2026-04-07T16:35:04.577Z"},"accession":"S-EPMC11250751","cross_references":{"pubmed":["38885590"],"doi":["10.1016/j.jhazmat.2024.134863"]}}