biostudies-literatureUnknown27(7)Zeng YThe resected pⅢA-N2 non-small-cell lung cancer (NSCLC) patients who could benefit from postoperative radiotherapy (PORT) are not well-defined. The study explored the role of PORT on EGFR mutant and wild-type NSCLC patients. We retrospectively searched for resected pIIIA-N2 lung adenocarcinoma patients who underwent EGFR mutation testing. 80 patients with EGFR wild-type and 85 patients with EGFR mutation were included. 62 patients received PORT. In overall population, the median disease-free survival (DFS) was improved in PORT arm compared to non-PORT arm (22.9 vs. 16.1 months; <i>p</i> = 0.036), along with higher 2-year locoregional recurrence-free survival (LRFS) rate (88.3% vs. 69.3%; <i>p</i> = 0.004). In EGFR wild-type patients, PORT was associated with a longer median DFS (23.3 vs. 17iScience110219https://www.ebi.ac.uk/biostudies/studies/S-EPMC11253153biostudies-literatureThe efficacy of postoperative radiotherapy in resected pⅢA-N2 EGFR mutant and wild-type lung adenocarcinoma.PMC11253153Zhang YZHe FJPeng YRLiu JQQiu ZHPu XXLi YLZhu HHuang KZeng YShi SHWu FZou JADeng CLiu XLHu CHHuang YLiu YFMa FfalseThe efficacy of postoperative radiotherapy in resected pⅢA-N2 EGFR mutant and wild-type lung adenocarcinoma.The resected pⅢA-N2 non-small-cell lung cancer (NSCLC) patients who could benefit from postoperative radiotherapy (PORT) are not well-defined. The study explored the role of PORT on EGFR mutant and wild-type NSCLC patients. We retrospectively searched for resected pIIIA-N2 lung adenocarcinoma patients who underwent EGFR mutation testing. 80 patients with EGFR wild-type and 85 patients with EGFR mutation were included. 62 patients received PORT. In overall population, the median disease-free survival (DFS) was improved in PORT arm compared to non-PORT arm (22.9 vs. 16.1 months; <i>p</i> = 0.036), along with higher 2-year locoregional recurrence-free survival (LRFS) rate (88.3% vs. 69.3%; <i>p</i> = 0.004). In EGFR wild-type patients, PORT was associated with a longer median DFS (23.3 vs. 172024-01-01T00:00:00Z2024 Jul2025-04-04T15:02:30.648Z2025-04-04T15:02:30.648ZS-EPMC112531533902179510.1016/j.isci.2024.110219