{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Grilli G"],"pubmed_abstract":["<h4>Background</h4>A sex-based evaluation of prognosis in heart failure (HF) is lacking.<h4>Methods and results</h4>We analyzed the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score registry, which includes HF with reduced ejection fraction (HFrEF) patients. A cross-validation procedure was performed to estimate weights separately for men and women of all MECKI score parameters: left ventricular ejection fraction (LVEF), hemoglobin, kidney function assessed by Modification of Diet in Renal Disease, blood sodium level, ventilation vs. carbon dioxide production slope, and peak oxygen consumption (peakVO<sub>2</sub>). The primary outcomes were the composite of all-cause mortality, urgent heart transplant, and implant of a left ventricle assist device. The dif"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["1390544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11253175"],"repository":["biostudies-literature"],"pubmed_title":["A matter of sex-persistent predictive value of MECKI score prognostic power in men and women with heart failure and reduced ejection fraction: a multicenter study."],"pmcid":["PMC11253175"],"pubmed_authors":["D'Assante R","Caravita S","Bandera F","Ricci R","Rossi M","Santolamazza C","Scardovi AB","Marchese G","Gugliandolo P","Palermo P","Ferraretti A","Carriere C","Moscucci F","Grilli G","Gallo G","Contini M","Pezzuto B","Battaia E","Cittadini A","Re F","Girola D","Crisci G","Senni M","Passino C","Passantino A","MECKI Score Research Group","Schaeffer M","Farina S","Sinagra G","Gussago C","Matassini MV","Corra U","Agostoni P","Rocca MD","Paolillo S","Raimondo R","Moretti M","Di Lenarda A","Campodonico J","Iorio A","Arcari L","Vastarella R","Guazzi M","Bertipaglia D","Vignati C","Gravino R","Capelli B","Marra AM","Bonomi A","Valente F","Perna E","Mapelli M","Piepoli M","Lombardi CM","Bussotti M","Capovilla T","Shkoza M","Correale M","Salzano A","Lagioia R","Limongelli G","Badagliacca R","Salvioni E","Cattadori G","Magri D","De Martino F","Metra M","Pietrucci F","Parati G","Pacileo G","Emdin M","Vigano E","Apostolo A","Halasz G","Mattavelli I","Filardi PP","Fiori E","Sciomer S","Scrutinio D","Baracchini N"],"additional_accession":[]},"is_claimable":false,"name":"A matter of sex-persistent predictive value of MECKI score prognostic power in men and women with heart failure and reduced ejection fraction: a multicenter study.","description":"<h4>Background</h4>A sex-based evaluation of prognosis in heart failure (HF) is lacking.<h4>Methods and results</h4>We analyzed the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score registry, which includes HF with reduced ejection fraction (HFrEF) patients. A cross-validation procedure was performed to estimate weights separately for men and women of all MECKI score parameters: left ventricular ejection fraction (LVEF), hemoglobin, kidney function assessed by Modification of Diet in Renal Disease, blood sodium level, ventilation vs. carbon dioxide production slope, and peak oxygen consumption (peakVO<sub>2</sub>). The primary outcomes were the composite of all-cause mortality, urgent heart transplant, and implant of a left ventricle assist device. The dif","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T15:01:54.377Z","creation":"2025-04-04T15:01:54.377Z"},"accession":"S-EPMC11253175","cross_references":{"pubmed":["39022621"],"doi":["10.3389/fcvm.2024.1390544"]}}