biostudies-literatureUnknown11Grilli G<h4>Background</h4>A sex-based evaluation of prognosis in heart failure (HF) is lacking.<h4>Methods and results</h4>We analyzed the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score registry, which includes HF with reduced ejection fraction (HFrEF) patients. A cross-validation procedure was performed to estimate weights separately for men and women of all MECKI score parameters: left ventricular ejection fraction (LVEF), hemoglobin, kidney function assessed by Modification of Diet in Renal Disease, blood sodium level, ventilation vs. carbon dioxide production slope, and peak oxygen consumption (peakVO₂). The primary outcomes were the composite of all-cause mortality, urgent heart transplant, and implant of a left ventricle assist device. The difFrontiers in cardiovascular medicine1390544https://www.ebi.ac.uk/biostudies/studies/S-EPMC11253175biostudies-literatureA matter of sex-persistent predictive value of MECKI score prognostic power in men and women with heart failure and reduced ejection fraction: a multicenter study.PMC11253175D'Assante RCaravita SBandera FRicci RRossi MSantolamazza CScardovi ABMarchese GGugliandolo PPalermo PFerraretti ACarriere CMoscucci FGrilli GGallo GContini MPezzuto BBattaia ECittadini ARe FGirola DCrisci GSenni MPassino CPassantino AMECKI Score Research GroupSchaeffer MFarina SSinagra GGussago CMatassini MVCorra UAgostoni PRocca MDPaolillo SRaimondo RMoretti MDi Lenarda ACampodonico JIorio AArcari LVastarella RGuazzi MBertipaglia DVignati CGravino RCapelli BMarra AMBonomi AValente FPerna EMapelli MPiepoli MLombardi CMBussotti MCapovilla TShkoza MCorreale MSalzano ALagioia RLimongelli GBadagliacca RSalvioni ECattadori GMagri DDe Martino FMetra MPietrucci FParati GPacileo GEmdin MVigano EApostolo AHalasz GMattavelli IFilardi PPFiori ESciomer SScrutinio DBaracchini NfalseA matter of sex-persistent predictive value of MECKI score prognostic power in men and women with heart failure and reduced ejection fraction: a multicenter study.<h4>Background</h4>A sex-based evaluation of prognosis in heart failure (HF) is lacking.<h4>Methods and results</h4>We analyzed the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score registry, which includes HF with reduced ejection fraction (HFrEF) patients. A cross-validation procedure was performed to estimate weights separately for men and women of all MECKI score parameters: left ventricular ejection fraction (LVEF), hemoglobin, kidney function assessed by Modification of Diet in Renal Disease, blood sodium level, ventilation vs. carbon dioxide production slope, and peak oxygen consumption (peakVO₂). The primary outcomes were the composite of all-cause mortality, urgent heart transplant, and implant of a left ventricle assist device. The dif2024-01-01T00:00:00Z20242025-04-04T15:01:54.377Z2025-04-04T15:01:54.377ZS-EPMC112531753902262110.3389/fcvm.2024.1390544